Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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The dynamic influence of commensal bacteria on the immune response to pathogens.
Michael C. Abt,David Artis +1 more
TL;DR: Examining the dynamic relationship that exists between the mammalian host, commensal bacteria and invasive pathogens can provide insights into the etiology of pathogenesis from an infection.
Journal ArticleDOI
Differential induction of TLR3-dependent innate immune signaling by closely related parasite species.
Daniel P. Beiting,Lucia Peixoto,Natalia S. Akopyants,Stephen M. Beverley,E. John Wherry,David A. Christian,Christopher A. Hunter,Igor E. Brodsky,David S. Roos +8 more
TL;DR: It is revealed that eukaryotic pathogens can be potent inducers of type I interferon and that related parasite species interact with this pathway in distinct ways.
Journal ArticleDOI
Silencing Suppressor of Cytokine Signaling-1 (SOCS1) in Macrophages Improves Mycobacterium tuberculosis Control in an Interferon-γ (IFN-γ)-dependent Manner
Berit Carow,Xiang qun Ye,Dolores Gavier-Widén,Sabin Bhuju,Wulf Oehlmann,Mahavir Singh,Markus Sköld,Lech Ignatowicz,Akihiko Yoshimura,Hans Wigzell,Martin E. Rottenberg +10 more
TL;DR: Using a conditional knockdown strategy in mice, it was found that SOCS1 expression by macrophages hampered M. tuberculosis clearance early after infection in vivo in an IFN-γ-dependent manner, and at later time points, SOCS 1 expression by non-macrophage cells protected the host from infection-induced detrimental inflammation.
Journal ArticleDOI
Bacterial polyphosphates interfere with the innate host defense to infection.
Julian Roewe,Georgios Stavrides,Marcel Strueve,Arjun Sharma,Federico Marini,Amrit Mann,Stephanie A. Smith,Ziya Kaya,Birgit Strobl,Mathias Mueller,Christoph Reinhardt,James H. Morrissey,Markus Bosmann +12 more
TL;DR: It is reported that mouse survival of peritoneal Escherichia coli sepsis is compromised by long-chain polyphosphates, and improves with bacterialpolyphosphatekinase deficiency or neutralization using recombinant exopolyphosphatase, and shows that long polyph phosphates produced by E. coli inhibit LPS-mediated inflammation and bacterial clearance in mice.
Journal ArticleDOI
Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral Responses.
TL;DR: IFI44L is a good target for treatment of diseases associated with excessive IFN levels and/or proinflammatory responses and for reduction of viral replication.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.