Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections.
Lukas Hunziker,Lukas Hunziker,Mike Recher,Andrew J. Macpherson,Adrian Ciurea,Stefan Freigang,Hans Hengartner,Rolf M. Zinkernagel +7 more
TL;DR: Hypergammaglobulinemia may arise when specific helper T cells recognize B cells that have processed viral antigens irrespective of the B cell receptor specificity, and this nonspecific B cell activation may contribute to antibody-mediated autoimmunity.
Journal ArticleDOI
Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity
TL;DR: Mouse RNase H2 is essential to remove ribonucleotides from the genome to prevent DNA damage and it is shown that inhibiting this enzyme results in cell death and cell death in mice.
Journal ArticleDOI
Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus.
Nadine Honke,Namir Shaabani,Giuseppe Cadeddu,Ursula R. Sorg,Dong-Er Zhang,Mirko Trilling,Karin Klingel,Martina Sauter,Reinhard Kandolf,Nicole Gailus,Nico van Rooijen,Christoph Burkart,Stephan Baldus,Melanie Grusdat,Max Löhning,Hartmut Hengel,Klaus Pfeffer,Masato Tanaka,Dieter Häussinger,Mike Recher,Philipp A. Lang,Philipp A. Lang,Karl S. Lang +22 more
TL;DR: It is found that enforced viral replication in marginal zone macrophages was an immunological mechanism that ensured the production of sufficient antigen for effective activation of the adaptive immune response.
Journal ArticleDOI
The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus
Miki Ida-Hosonuma,Takuya Iwasaki,Tomoki Yoshikawa,Noriyo Nagata,Yuko Sato,Tetsutaro Sata,Mitsutoshi Yoneyama,Takashi Fujita,Choji Taya,Hiromichi Yonekawa,Satoshi Koike +10 more
TL;DR: It is considered that poliovirus replication was observed in the nontarget tissues of PVR-transgenic/Ifnar knockout mice because the IFN response was null in all tissues.
Journal ArticleDOI
STAT2 deficiency and susceptibility to viral illness in humans
Sophie Hambleton,Stephen Goodbourn,Dan F. Young,Paul Dickinson,Siti Mardhiana Mohamad,Siti Mardhiana Mohamad,M Valappil,Naomi McGovern,Andrew J. Cant,Andrew J. Cant,Scott Hackett,Peter Ghazal,Neil V. Morgan,Richard E. Randall +13 more
TL;DR: The findings imply that type I IFN signaling [through interferon-stimulated gene factor 3 (ISGF3)] is surprisingly not essential for host defense against the majority of common childhood viral infections.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.