Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
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The mannose receptor mediates induction of IFN-alpha in peripheral blood dendritic cells by enveloped RNA and DNA viruses.
TL;DR: It is demonstrated that stimulation of IFN-alpha synthesis by HSV is inhibited by a number of monosaccharides, including fucose, N- acetylglucosamine, and N-acetylgalactosamine as well as the yeast polysaccharide mannan, supporting a role for lectin(s) in theIFN- alpha stimulation pathway.
Journal ArticleDOI
VSV-tumor selective replication and protein translation
TL;DR: Using VSV as a model, some of the recent developments in the fields of innate immunity and translational regulation that may help explain mechanisms of viral oncolysis are discussed.
Journal ArticleDOI
Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide
Sharline Madera,Moritz Rapp,Matthew A. Firth,Joshua N. Beilke,Lewis L. Lanier,Joseph C. Sun,Joseph C. Sun +6 more
TL;DR: It is shown that NK cells unable to receive type I IFN signals during MCMV infection have defective expansion and memory cell formation, possessing increased susceptibility to apoptosis due to NK cell–mediated fratricide.
Journal ArticleDOI
A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate.
Lorena Sanchez-Felipe,Lorena Sanchez-Felipe,Thomas Vercruysse,Sapna Sharma,Sapna Sharma,Ji Ma,Ji Ma,Viktor Lemmens,Viktor Lemmens,Dominique Van Looveren,Mahadesh Prasad Arkalagud Javarappa,Mahadesh Prasad Arkalagud Javarappa,Robbert Boudewijns,Robbert Boudewijns,Bert Malengier-Devlies,Laurens Liesenborghs,Laurens Liesenborghs,Suzanne J.F. Kaptein,Suzanne J.F. Kaptein,Carolien De Keyzer,Carolien De Keyzer,Lindsey Bervoets,Lindsey Bervoets,Sarah Debaveye,Sarah Debaveye,Madina Rasulova,Laura Seldeslachts,Li Hsin Li,Li Hsin Li,Sander Jansen,Sander Jansen,Michael Bright Yakass,Michael Bright Yakass,Michael Bright Yakass,Babs E. Verstrepen,Kinga P. Böszörményi,Gwendoline Kiemenyi-Kayere,Nikki van Driel,Osbourne Quaye,Osbourne Quaye,Xin Zhang,Xin Zhang,Sebastiaan ter Horst,Sebastiaan ter Horst,Niraj Mishra,Niraj Mishra,Niraj Mishra,Ward Deboutte,Jelle Matthijnssens,Lotte Coelmont,Lotte Coelmont,Corinne Vandermeulen,Elisabeth Heylen,Valentijn Vergote,Dominique Schols,Zhongde Wang,Willy M. J. M. Bogers,Thijs Kuiken,Ernst J. Verschoor,Christopher Cawthorne,Koen Van Laere,Ghislain Opdenakker,Greetje Vande Velde,Birgit Weynand,Dirk E. Teuwen,Patrick Matthys,Johan Neyts,Johan Neyts,Hendrik Jan Thibaut,Kai Dallmeier,Kai Dallmeier +70 more
TL;DR: The quality of immune responses triggered and the rapid kinetics by which protective immunity can be mounted already after a single dose warrant further development of this potent SARS-CoV-2 vaccine candidate.
Journal ArticleDOI
Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection.
Yejin Kim,Hyemin Kim,Seyeon Bae,Jiwon Choi,Sun Young Lim,Naeun Lee,Joo Myung Kong,Young-il Hwang,Jae Seung Kang,Wang Jae Lee +9 more
TL;DR: Vitamin C shows in vivo anti-viral immune responses at the early time of infection, especially against influenza virus, through increased production of IFN-α/β.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
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Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.