Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression
TL;DR: GRIP1 plays a cofactor role in innate immunity and is identified as a novel target for glucocorticoid immunosuppression, as well as a specific disruption of TLR3–IRF3 pathway, not of autocrine IFN signaling.
Journal ArticleDOI
Dengue Virus Infects Macrophages and Dendritic Cells in a Mouse Model of Infection
TL;DR: It is found that the initial cellular tropism of DENV in mice is similar to that reported in humans, thereby paving the way for investigation of cellular Tropism and pathogenesis ofDENV in primary and secondary infections.
Journal ArticleDOI
STING-dependent sensing of self-DNA drives silica-induced lung inflammation
Sulayman Benmerzoug,Sulayman Benmerzoug,Stéphanie Rose,Stéphanie Rose,Badreddine Bounab,Badreddine Bounab,David Gosset,Laure Duneau,Laure Duneau,Pauline Chenuet,Lucile Mollet,Marc Le Bert,Marc Le Bert,Christopher Lambers,Silvana Geleff,Michael Roth,Louis Fauconnier,Delphine Sedda,Delphine Sedda,Clarisse Carvalho,Clarisse Carvalho,Olivier Perche,Olivier Perche,David Laurenceau,David Laurenceau,Bernhard Ryffel,Bernhard Ryffel,Lionel Apetoh,Ahmet Kiziltunc,Hakan Uslu,Fadime Sultan Albez,Metin Akgun,Dieudonnée Togbe,Valérie F. J. Quesniaux,Valérie F. J. Quesniaux +34 more
TL;DR: It is shown that silica induces cell death and release of mitochondria and genomic DNA, which are sensed by STING with or without involving cGAS, respectively, for IL-1 induction and lung inflammation.
Journal ArticleDOI
B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity
E. Ashley Moseman,Matteo Iannacone,Lidia Bosurgi,Lidia Bosurgi,Elena Tonti,Nicolas Chevrier,Nicolas Chevrier,Alexei V. Tumanov,Yang Xin Fu,Nir Hacohen,Nir Hacohen,Ulrich H. von Andrian +11 more
TL;DR: Although B cells are essential for survival during VSV infection, their contribution involves the provision of innate differentiation and maintenance signals to macrophages, rather than adaptive immune mechanisms.
Journal ArticleDOI
Key role of T cell defects in age-related vulnerability to West Nile virus.
James D. Brien,Jennifer L. Uhrlaub,Jennifer L. Uhrlaub,Alec J. Hirsch,Clayton A. Wiley,Janko Nikolich-Zugich,Janko Nikolich-Zugich +6 more
TL;DR: It is demonstrated that death correlates with increased viral titers in the brain and that this loss of virus control with age was the result of defects in the CD4 and CD8 T cell response against WNV, identifying potential targets for immunomodulation and treatment to combat lethal WNV infection in the elderly.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.