Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS
Angela Dann,Hendrik Poeck,Hendrik Poeck,Andrew L. Croxford,Stefanie Gaupp,Katrin Kierdorf,Markus Knust,Dietmar Pfeifer,Cornelius Maihoefer,Stefan Endres,Stefan Endres,Ulrich Kalinke,Sven G. Meuth,Heinz Wiendl,Klaus-Peter Knobeloch,Shizuo Akira,Ari Waisman,Gunther Hartmann,Marco Prinz +18 more
TL;DR: RLHs are identified as negative regulators of TH1 and TH17 responses in the CNS, demonstrate a protective role of the RLH pathway for brain inflammation, and establish oligonucleotide ligands of RLHs as potential therapeutics for the treatment of multiple sclerosis.
Journal ArticleDOI
Mechanisms for interferon-α-induced depression and neural stem cell dysfunction
Lian Shun Zheng,Lian Shun Zheng,Seiji Hitoshi,Seiji Hitoshi,Naoko Kaneko,Keizo Takao,Tsuyoshi Miyakawa,Tsuyoshi Miyakawa,Yasuhito Tanaka,Hongjing Xia,Ulrich Kalinke,Koutaro Kudo,Shigenobu Kanba,Kazuhiro Ikenaka,Kazunobu Sawamoto +14 more
TL;DR: Insight is provided for understanding the neuropathology underlying IFN-α-induced depression and for developing new strategies for the prevention and treatment ofIFN- α-induced depressive effects.
Journal ArticleDOI
Protection against lethal Rift Valley fever virus (RVFV) infection in transgenic IFNAR(-/-) mice induced by different DNA vaccination regimens.
TL;DR: Interestingly, the combination of both vaccine constructs induced specific lymphoblast proliferation upon stimulation with a recombinant nucleoprotein, which could be directly related to the induction of neutralizing antibodies against them.
Journal ArticleDOI
Interferon-β Plays a Detrimental Role in Experimental Traumatic Brain Injury by Enhancing Neuroinflammation That Drives Chronic Neurodegeneration.
James P. Barrett,Rebecca J. Henry,Kari Ann Shirey,Sarah J. Doran,Oleg Makarevich,Rodney M. Ritzel,Victoria A. Meadows,Stefanie N. Vogel,Alan I. Faden,Bogdan A. Stoica,Bogdan A. Stoica,David J. Loane,David J. Loane +12 more
TL;DR: It is demonstrated that TBI is followed by robust activation of type I IFN pathways, which have been implicated in microglial-associated neuroinflammation and chronic neurodegeneration, and IFN-β may be a potential therapeutic target for TBI.
Journal ArticleDOI
Hantaan Virus Infection Causes an Acute Neurological Disease That Is Fatal in Adult Laboratory Mice
Dominic Wichmann,Hermann Josef Gröne,Michael Frese,Jovan Pavlovic,Bärbel Anheier,Otto Haller,Hans Dieter Klenk,Heinz Feldmann +7 more
TL;DR: It is demonstrated that several strains of adult Mus musculus domesticus were susceptible to Hantaan virus infection when infected intraperitoneally, indicating an important role of interferon-induced antiviral defense mechanisms in Hantavirus pathogenesis.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
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Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.