Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
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Interferon-driven deletion of antiviral B cells at the onset of chronic infection.
Benedict Fallet,Kerstin Narr,Yusuf I. Ertuna,Melissa Remy,Rami Sommerstein,Karen Cornille,Mario Kreutzfeldt,Nicolas Page,Gert Zimmer,Florian Geier,Tobias Straub,Hanspeter Pircher,Kevin Larimore,Kevin Larimore,Philip D. Greenberg,Philip D. Greenberg,Doron Merkler,Daniel D. Pinschewer +17 more
TL;DR: Using adoptive transfer experiments in the context of a chronic lymphocytic choriomeningitis virus infection of mice, rapid depletion of virus-specific B cells is documented that coincided with the early type I interferon (IFN-I) response to infection.
Journal ArticleDOI
Interferons, Mx Genes, and Resistance to Influenza Virus
TL;DR: The MxA protein has been shown to be necessary and sufficient to protect against influenza virus infection because the resistance does not require a functioning immune system as mentioned in this paper. But, in contrast to the murine Mx system, a functioning immunity system is necessary for protection.
Journal ArticleDOI
Type I Interferons Produced by Resident Renal Cells May Promote End-Organ Disease in Autoantibody-Mediated Glomerulonephritis
Anna-Marie Fairhurst,Chun Xie,Yuyang Fu,Andrew Wang,Christopher Boudreaux,Xin J. Zhou,Ricardo Cibotti,Anthony J. Coyle,John E. Connolly,Edward K. Wakeland,Chandra Mohan +10 more
TL;DR: Collectively, these studies indicate that an important contribution of IFN-I toward the disease pathology seen in systemic autoimmunity may be exercised at the level of the end-organ.
Journal ArticleDOI
The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination.
Ren-Huan Xu,Matthew Cohen,Yong Tang,Eric Lazear,J. Charles Whitbeck,Roselyn J. Eisenberg,Gary H. Cohen,Luis J. Sigal +7 more
TL;DR: This work demonstrates that immunization with recombinant type I IFN bp protects mice from lethal mousepox and provides proof of concept that effective antiviral vaccines can be made to prevent disease by targeting virulence factors as an alternative to the traditional approach that attempts to prevent infection by virus neutralization.
Journal ArticleDOI
Dna vaccination against virus infection and enhancement of antiviral immunity following consecutive immunization with dna and viral vectors
TL;DR: Progress in DNA‐based antiviral immunoprophylaxis is reviewed and a consecutive immunization protocol consisting of a priming dose of vaccine antigen encoded in DNA plasmids followed by a booster with the same antigen encoding in recombinant fowlpox virus vectors is described.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.