Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Journal ArticleDOI
The Role of Antibody Concentration and Avidity in Antiviral Protection
Mf Bachmann,Ulrich Kalinke,Alana Althage,Giulia Freer,Christoph Burkhart,Hp Roost,Michel Aguet,Hans Hengartner,R M Zinkernagel +8 more
TL;DR: In vivo, protection was independent of immunoglobulin subclass, avidity, neutralization rate constant, and in vitro neutralizing activity; above a minimal avidity threshold, protection depended simply on a minimum serum concentration, offering hope for the development of adoptive therapy with neutralizing antibodies.
Journal ArticleDOI
Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia.
Elisabeth Kamphuis,Tobias Junt,Tobias Junt,Tobias Junt,Zoe Waibler,Zoe Waibler,Zoe Waibler,Reinhold Förster,Reinhold Förster,Reinhold Förster,Ulrich Kalinke,Ulrich Kalinke,Ulrich Kalinke +12 more
TL;DR: In this paper, the authors investigated lymphopenia in mice infected with vesicular stomatitis virus (VSV) or treated with the Toll-like receptor (TLR) agonists poly(I:C) and R-848.
Journal ArticleDOI
Cytokines and immunity to viral infections
Ian A. Ramshaw,Alistair J. Ramsay,Gunasegaran Karupiah,Michael S. Rolph,Surendran Mahalingam,Janet Ruby +5 more
TL;DR: Surprisingly, not only the TNFR1, but also theTNFR2, was able to mediate the antiviral effects of TNF‐α in viv, whilst the antiv viral activity observed following CD40‐CD40L interaction is a newly defined function which may involve apoptosis of infected cells.
Journal ArticleDOI
The type I interferon receptor: structure, function, and evolution of a family business.
TL;DR: A proposal is made that the IFN receptor, with its subunits IFNAR-1 and IFnAR-2, presents two separate ligand binding sites, and this double structure is both necessary and sufficient to ensure that the different IFN are recognized and can act selectively.
Journal ArticleDOI
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
Si Ming Man,Si Ming Man,Rajendra Karki,R. K. Subbarao Malireddi,Geoffrey Neale,Peter Vogel,Masahiro Yamamoto,Mohamed Lamkanfi,Mohamed Lamkanfi,Thirumala-Devi Kanneganti +9 more
TL;DR: This work has found that the transcription factor IRF1 was required for activation of the AIM2 inflammasome during infection with the Francisella tularensis subspecies novicida, whereas engagement of the CVs by mouse cytomegalovirus (MCMV) or transfected double-stranded DNA did not require IRF 1.
References
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Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
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Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.