Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
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Alpha beta and gamma delta T-cell networks and their roles in natural resistance to viral infections.
Raymond M. Welsh,Meei Y. Lin,Barbara L. Lohman,Steven M. Varga,Christopher C. Zarozinski,Liisa K. Selin +5 more
TL;DR: Memory αβ T cells can, like γδ T cells and NK cells, provide natural immunity to viral infections and are suggested to mediate both immunopathology and protective immunity at early stages of the second viruses infection.
Journal ArticleDOI
A Lymphotoxin-IFN-β Axis Essential for Lymphocyte Survival Revealed during Cytomegalovirus Infection
Theresa A. Banks,Sandra Rickert,Chris A. Benedict,Lisa Ma,Mira Ko,Joshua Meier,Won Ha,Kirsten Schneider,Steven W. Granger,Olga Turovskaya,Dirk Elewaut,Dennis C. Otero,Anthony R. French,Stanley C. Henry,John D. Hamilton,Stefanie Scheu,Klaus Pfeffer,Carl F. Ware +17 more
TL;DR: IFN-αβR−/− mice were found to exhibit profound lymphocyte death during MCMV infection, thus providing a potential mechanistic link between type 1 IFN induction and lymphocyte survival through a LTαβ-dependent pathway important forMCMV host defense.
Journal ArticleDOI
Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells
Natalia V. Giltiay,Craig P. Chappell,Xizhang Sun,Nikita S. Kolhatkar,Thomas H. Teal,Alice E. Wiedeman,Jinoh Kim,Lena Tanaka,Matthew B. Buechler,Matthew B. Buechler,Jessica A. Hamerman,Jessica A. Hamerman,Thereza Imanishi-Kari,Edward A. Clark,Keith B. Elkon +14 more
TL;DR: Transgenic expression of TLR7 results in the expansion and hyperactivation of T1 B cells in response to endogenous RNA complexes, leading to increased autoantibody production.
Journal ArticleDOI
Regulation of Inflammatory Monocyte/Macrophage Recruitment from the Bone Marrow during Murine Cytomegalovirus Infection: Role for Type I Interferons in Localized Induction of CCR2 Ligands
TL;DR: A critical role for inflammatory cytokines is revealed in stimulating production of CCR2-binding chemokines from F4/80+ cells in the bone marrow, and they suggest that local production of chemokine supports monocyte/macrophage egress from theBone marrow into the blood during a virus infection.
Journal ArticleDOI
Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell.
Maritza Puray-Chavez,Kyle M. LaPak,Travis P. Schrank,Jennifer L Elliott,Dhaval P. Bhatt,Megan J. Agajanian,Ria Jasuja,Dana Q. Lawson,Keanu Davis,Paul W. Rothlauf,Paul W. Rothlauf,Zhuoming Liu,Heejoon Jo,Nakyung Lee,Kasyap Tenneti,Jenna E. Eschbach,Christian Shema Mugisha,Emily M. Cousins,Erica W. Cloer,Hung R. Vuong,Laura A. VanBlargan,Adam L. Bailey,Pavlo Gilchuk,James E. Crowe,Michael S. Diamond,D. Neil Hayes,Sean P. J. Whelan,Amjad Horani,Steven L. Brody,Dennis Goldfarb,M. Ben Major,Sebla B. Kutluay +31 more
TL;DR: In this article, the authors identify human H522 lung adenocarcinoma cells as naturally permissive to SARS-CoV-2 infection despite complete absence of angiotensin-converting enzyme 2 (ACE2) expression.
References
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Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.