Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis
TL;DR: Intranasal immunization with flagellin and the F1 antigen was protective against intranasAL challenge with virulent Y. pestis CO92, with 93 to 100% survival of immunized mice, and vaccination of cynomolgus monkeys with flagesllin induced a robust antigen-specific IgG antibody response.
Journal ArticleDOI
The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C).
Colm Cunningham,Suzanne Campion,Suzanne Campion,Jessica L. Teeling,Jessica L. Teeling,Leigh M. Felton,Leigh M. Felton,V.H. Perry,V.H. Perry +8 more
TL;DR: Clear CNS effects of peripheral TLR3 stimulation are demonstrated and will be useful in studying aspects of the effects of systemic viral infection on brain function in both normal and pathological situations.
Journal ArticleDOI
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity
Jennifer Eve Fenner,Robyn Starr,Ann L. Cornish,Ann L. Cornish,Jian-Guo Zhang,Donald Metcalf,Robert D. Schreiber,Kathleen C. F. Sheehan,Douglas J. Hilton,Warren S. Alexander,Paul J. Hertzog +10 more
TL;DR: SOCS1 is an important in vivo inhibitor of type I interferon signaling and contributes to balancing its beneficial antiviral versus detrimental proinflammatory effects on innate immunity.
Journal ArticleDOI
Activation of Invariant NKT Cells by Toll-like Receptor 9-Stimulated Dendritic Cells Requires Type I Interferon and Charged Glycosphingolipids
Christophe Paget,Christophe Paget,Thierry Mallevaey,Thierry Mallevaey,Anneliese O. Speak,David Torres,David Torres,Josette Fontaine,Josette Fontaine,Kathleen C. F. Sheehan,Monique Capron,Monique Capron,Bernhard Ryffel,Christelle Faveeuw,Christelle Faveeuw,Maria Leite de Moraes,Frances M. Platt,François Trottein,François Trottein +18 more
TL;DR: iNKT cell activation in response to TLR9 stimulation required combined synthesis of type I interferon and de novo production of charged beta-linked glycosphingolipid(s) by DCs, which underline the role of TLR 9 in iN KT cell activation and might have relevance to infectious diseases and cancer.
Journal ArticleDOI
The Vaccinia Virus Soluble Alpha/Beta Interferon (IFN) Receptor Binds to the Cell Surface and Protects Cells from the Antiviral Effects of IFN
TL;DR: This work has found that after secretion B18R binds to both uninfected and infected cells, and represents a novel strategy of virus immune evasion in which secreted IFN-α/β receptors not only bind the soluble cytokine but also bind to uninfecting cells and protect them from the antiviral effects of IFn- α/β, maintaining the cells' susceptibility to virus infections.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.