Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
More filters
Journal ArticleDOI
Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage.
Anannya Bhattacharya,Ahmed N. Hegazy,Nikolaus Deigendesch,Lindsay Kosack,Jovana Cupovic,Richard Kumaran Kandasamy,Andrea Hildebrandt,Doron Merkler,Anja A. Kühl,Bojan Vilagos,Christopher Schliehe,Isabel Panse,Isabel Panse,Kseniya Khamina,Hatoon Baazim,Isabelle C. Arnold,Lukas Flatz,Haifeng C. Xu,Philipp A. Lang,Alan Aderem,Akinori Takaoka,Giulio Superti-Furga,Jacques Colinge,Burkhard Ludewig,Max Löhning,Max Löhning,Andreas Bergthaler +26 more
TL;DR: The results delineate IFN-I mediated oxidative stress as a key mediator of virus-induced liver damage and describe a mechanism of innate-immunity-driven pathology, linking IFn-I signaling with antioxidant host defense and infection-associated tissue damage.
Journal ArticleDOI
Mucosal Cytokine Therapy: Marked Antiviral and Antitumor Activity
TL;DR: The results suggest that mucosal Th1 cytokine therapy induces a soluble factor or activates a specific cell population in the lymphoid or epithelial tissue of the oropharyngeal cavity, which potentiates elimination of virus-infected or neoplasic cells systemically.
Journal ArticleDOI
The nitric oxide pathway provides innate antiviral protection in conjunction with the type I interferon pathway in fibroblasts.
TL;DR: It is shown that in response to dsRNA, nitric oxide is rapidly produced in primary fibroblasts, and this pathway serves as a secondary strategy to protect the host against viral infection in key cell types that largely rely on the type I interferon system for antiviral protection.
Journal ArticleDOI
Human Herpesvirus 6A Infection in CD46 Transgenic Mice: Viral Persistence in the Brain and Increased Production of Proinflammatory Chemokines via Toll-Like Receptor 9
TL;DR: This study presents a first murine model for HHV-6A-induced brain infection and suggests a role for TLR9 in theHHV- 6A-initiated production of proinflammatory chemokines in the brain, opening novel perspectives for the study of virus-associated neuropathology.
Journal ArticleDOI
Human type I interferon receptor, IFNAR, is a heavily glycosylated 120-130 kD membrane protein.
Leona E. Ling,Mohammad Zafari,Donna Reardon,Margot Brickelmeier,Susan Goelz,Christopher D. Benjamin +5 more
TL;DR: Variations in the mean value and the range of molecular mass between IFNAR in different cell lines suggest differences in glycosylation, although there may also be a small amount O-linked oligosaccharide.
References
More filters
Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.