Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma
Joel N. Kline,Arthur M. Krieg,Thomas J. Waldschmidt,Zuhair K. Ballas,Vipul V. Jain,Thomas R. Businga +5 more
TL;DR: These data indicate that CpG-ODNs prevent the generation of T(H2)-like immune responses by multiple mechanisms, which involve, but do not require, IL-12 and IFN-gamma.
Journal ArticleDOI
Biological assays for interferons.
TL;DR: A critical overview of the development, specificity, standardisation and present use of the various biological assay methods now available for the quantification of IFN activity is given.
Journal ArticleDOI
Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell.
Ling-Jun Ho,Li-Feng Hung,Chun-Yi Weng,Wan-Lin Wu,Ping Chou,Yi-Ling Lin,Deh-Ming Chang,Tong-Yuan Tai,Jenn-Haung Lai +8 more
TL;DR: The preinfection treatment with either IFN-α or IFn-γ effectively armed DCs and limited viral production in infected cells, however, after infection, DV developed mechanisms to counteract the protection from lately added IF-α, but not IF-γ, suggesting that DV may antagonize the antiviral effect of IF- α.
Journal ArticleDOI
A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses
Vladimir Litvak,Alexander V. Ratushny,Alexander V. Ratushny,Aaron E. Lampano,Frank Schmitz,Albert C. Huang,Ayush T. Raman,Alistair G. Rust,Andreas Bergthaler,John D. Aitchison,John D. Aitchison,Alan Aderem +11 more
TL;DR: The data suggest that the FOXO3–IRF7 regulatory circuit represents a novel mechanism for establishing the requisite set points in the interferon pathway that balances the beneficial effects and deleterious sequelae of the antiviral response.
Journal ArticleDOI
Native hepatitis B virions and capsids visualized by electron cryomicroscopy.
Kelly A. Dryden,Stefan Wieland,Christina Whitten-Bauer,John L. Gerin,Francis V. Chisari,Mark Yeager,Mark Yeager +6 more
TL;DR: In this paper, the structure and assembly of the hepatitis B virus (HBV) capsid was examined using electron cryomicroscopy (cryo-EM) and image analysis to examine HBV virions (Dane particles) isolated from patient serum.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.