Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection
TL;DR: The haematopoietic response to chronic bacterial infection involves the activation not only of intermediate blood progenitors but of long-term repopulating HSCs as well, and implicate IFN-γ both as a regulator of H SCs during homeostasis and under conditions of infectious stress.
Journal ArticleDOI
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes
Rajendra Karki,Bhesh Raj Sharma,Shraddha Tuladhar,Evan P. Williams,Lillian Zalduondo,Parimal Samir,Min Zheng,Balamurugan Sundaram,Balaji Banoth,R. K. Subbarao Malireddi,Patrick Schreiner,Geoffrey Neale,Peter Vogel,Richard Webby,Colleen B. Jonsson,Thirumala-Devi Kanneganti +15 more
TL;DR: It is suggested that blocking the cytokine-mediated inflammatory cell death signaling pathway identified here may benefit patients with COVID-19 or other infectious and autoinflammatory diseases by limiting tissue damage/inflammation.
Journal ArticleDOI
Subcellular Localization of Toll-Like Receptor 3 in Human Dendritic Cells
Misako Matsumoto,Kenji Funami,Masako Tanabe,Hiroyuki Oshiumi,Masashi Shingai,Yoshiyuki Seto,Akitsugu Yamamoto,Tsukasa Seya +7 more
TL;DR: Immunoelectron microscopic analysis revealed that TLR3, when stably expressed in the murine B cell line Ba/F3, was specifically accumulated in multivesicular bodies, a subcellular compartment situated in endocytic trafficking pathways, which may reflect participation of cell type-specific multiple pathways in antiviral IFN induction viaTLR3.
Journal ArticleDOI
Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency.
Stéphanie Dupuis,Emmanuelle Jouanguy,Sami Al-Hajjar,Claire Fieschi,Ibrahim Al-Mohsen,Suliman Al-Jumaah,Kun Yang,Ariane Chapgier,Celine Eidenschenk,Pierre Eid,Abdulaziz Al Ghonaium,Haysam Tufenkeji,Husn H. Frayha,Suleiman Al-Gazlan,Hassan Al-Rayes,Robert D. Schreiber,Ion Gresser,Jean-Laurent Casanova,Jean-Laurent Casanova +18 more
TL;DR: Two unrelated infants homozygous with respect to mutated STAT1 alleles are reported, both infants suffered from mycobacterial disease, but unlike individuals with IFN-γR deficiency, both died of viral disease.
Journal ArticleDOI
INTERFEROME v2.0: an updated database of annotated interferon-regulated genes
Irina Rusinova,Samuel C. Forster,Simon Xiaoming Yu,Anitha Kannan,Marion Masse,Helen E. Cumming,Ross Chapman,Paul J. Hertzog +7 more
TL;DR: Given the importance of IFN to innate immune responses in infectious, inflammatory diseases and cancer, this upgrade of the Interferome to version 2.0 will facilitate the identification of gene signatures of importance in the pathogenesis of these diseases.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.