Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Journal ArticleDOI
Interferons Regulate the Phenotype of Wild-type and Mutant Herpes Simplex Viruses In Vivo
David A. Leib,Travis Harrison,Kathleen M. Laslo,Michael A. Machalek,Nathaniel J. Moorman,Herbert W. Virgin +5 more
TL;DR: IFNs play a major role in limiting mutant and wild-type HSV replication in the cornea and in the nervous system and an unsuspected role for host factors in defining the phenotypes of some HSV mutants in vivo is demonstrated.
Journal ArticleDOI
Interferons and viral infections.
Volker Fensterl,Ganes C. Sen +1 more
TL;DR: The effectiveness of theinterferon system in counteracting viral infections is reflected by the multitude of inhibitors of interferon induction or interferons action that are encoded by many viruses, preventing their eradication and resulting in the continued coexistence of viruses and vertebrates.
Journal ArticleDOI
Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression.
TL;DR: Influenza A virus-induced IFN-alpha/beta is essential in host's antiviral defence by activating the expression of antiviral Mx, PKR and oligoadenylate synthetase genes.
Journal ArticleDOI
Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection
Kenya Honda,Shinya Sakaguchi,Chigusa Nakajima,Ai Watanabe,Hideyuki Yanai,Misako Matsumoto,Toshiaki Ohteki,Tsuneyasu Kaisho,Akinori Takaoka,Shizuo Akira,Tsukasa Seya,Tadatsugu Taniguchi +11 more
TL;DR: It is shown that IFN-α/β signaling is selectively required for the maturation of DCs induced by double-stranded RNA or viral infection in vitro, and that the DCs stimulated in vivo by these agents can migrate into the T cell zone of the spleen but fail to mature without the IFN signal.
Journal ArticleDOI
New Mouse Model for Dengue Virus Vaccine Testing
TL;DR: It is demonstrated that AG129 mice are a promising small animal model for DEN virus vaccine trials, and survival times increased following passive transfer of anti-DEN polyclonal antibody.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.