Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Journal ArticleDOI
NK Cell–Like Behavior of Vα14i NK T Cells during MCMV Infection
TL;DR: It is found that Vα14i NK T cells become activated and produce significant levels of IFN-γ, but do not proliferate or produce IL-4 following MCMV infection, and mortality is increased in CD1d−/− mice in response to high dose MCMv infection when compared to heterozygote littermate controls.
Journal ArticleDOI
The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection
TL;DR: The data support a model in which Zbtb32 acts as a cellular 'hub' through which proinflammatory signals instruct a 'proliferation-permissive' state in NK cells, thereby allowing their prolific expansion in response to viral infection.
Journal ArticleDOI
Identification of a cDNA encoding channel catfish interferon
TL;DR: Analysis of the deduced amino acid sequence of CF IFN showed low levels of identity/similarity to a panel of mammalian and avian IFN proteins, and markedly higher similarity to a recently identified zebrafish IFN.
Journal ArticleDOI
Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-β Signaling
Christelle Bourgeois,Olivia Majer,Ingrid E. Frohner,Iwona Lesiak-Markowicz,Kwang-Soo Hildering,Walter Glaser,Silvia Stockinger,Thomas Decker,Shizuo Akira,Mathias Müller,Karl Kuchler +10 more
TL;DR: In this article, the authors demonstrate a mechanism mediating a strong IFN-β response in mouse conventional dendritic cells challenged by Candida spp., subsequently orchestrating IFNα/β receptor 1-dependent intracellular STAT1 activation and IFN regulatory factor (IRF) 7 expression.
Journal ArticleDOI
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells
Laura Schaupp,Sabine Muth,Leif Rogell,Michael Kofoed-Branzk,Felix Melchior,Stefan Lienenklaus,Stephanie C. Ganal-Vonarburg,Matthias Klein,Fabian Guendel,Tobias Hain,Kristian Schütze,Ulrike Grundmann,Vanessa Schmitt,Martina Dorsch,Julia Spanier,Pia-Katharina Larsen,Thomas Schwanz,Sven Jäckel,Christoph Reinhardt,Tobias Bopp,Sven Danckwardt,Karsten Mahnke,Gitta Anne Heinz,Mir-Farzin Mashreghi,Pawel Durek,Ulrich Kalinke,Oliver Kretz,Oliver Kretz,Tobias B. Huber,Siegfried Weiss,Christoph Wilhelm,Andrew J. Macpherson,Hansjörg Schild,Andreas Diefenbach,Hans Christian Probst +34 more
TL;DR: It is reported that the indigenous microbiota controls constitutive production of type I interferons (IFN-I) by plasmacytoid DCs in mice, and tonic IFNAR signaling instructs a specific epigenomic and metabolic basal state that poises cDCs for future pathogen combat.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
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Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.