Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Journal ArticleDOI
Variation in Interferon Sensitivity and Induction among Strains of Eastern Equine Encephalitis Virus
Patricia V. Aguilar,Slobodan Paessler,Anne-Sophie Carrara,Samuel Baron,Joyce Poast,Eryu Wang,Abelardo C. Moncayo,Michael Anishchenko,Douglas M. Watts,Robert B. Tesh,Scott C. Weaver +10 more
TL;DR: In vivo results did not support the hypothesis that NA strains are more virulent in humans due to their greater ability to counteract the IFN response, and there is evidence that IFN is important in controlling disease.
Journal ArticleDOI
Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine
Sanghyun Lee,Craig B. Wilen,Anthony Orvedahl,Broc T. McCune,Ki-Wook Kim,Robert C. Orchard,Stefan T. Peterson,Timothy J. Nice,Megan T. Baldridge,Herbert W. Virgin +9 more
TL;DR: It is determined that a small number of intestinal epithelial cells (IECs) serve as the reservoir for fecal shedding and persistence of murine norovirus and interferon-lambda (IFN-λ) is a key host determinant blocking MNoV infection in IECs.
Journal ArticleDOI
Severe combined immunodeficiency in stimulator of interferon genes (STING) V154M/wild-type mice.
Delphine Bouis,Peggy Kirstetter,Peggy Kirstetter,Florent Arbogast,Florent Arbogast,Delphine Lamon,Virginia Delgado,Sophie Jung,Claudine Ebel,Claudine Ebel,Hugues Jacobs,Anne-Marie Knapp,Nadia Jeremiah,Alexandre Belot,Thierry Martin,Yanick J. Crow,Yanick J. Crow,Yanick J. Crow,Isabelle André-Schmutz,Isabelle André-Schmutz,Anne-Sophie Korganow,Frédéric Rieux-Laucat,Frédéric Rieux-Laucat,Pauline Soulas-Sprauel,Pauline Soulas-Sprauel +24 more
TL;DR: STING gain‐of‐function mice developed an interferon‐independent SCID phenotype with a T‐cell, B‐ cell, and natural killer cell developmental defect and hypogammaglobulinemia that is associated with signs of inflammation in lungs and kidneys.
Journal ArticleDOI
Influenza virus infection causes global respiratory tract B cell response modulation via innate immune signals.
W. L. William Chang,Elizabeth S. Coro,Friederike C. Rau,Yuanyuan Xiao,David J. Erle,Nicole Baumgarth +5 more
TL;DR: It is concluded that type I IFN is the main “third” B cell signal following influenza infection causing early trapping of B cells in regional lymph nodes and, at a time when cognate T cell help is rare, enhancing their propensity to interact with innate immune cells for noncognate stimulation.
Journal ArticleDOI
Apaf-1-independent programmed cell death in mouse development
TL;DR: Pumped-up programmed cell death in mouse development, which normally proceeds in an efficient Apaf-1-depenent mechanism, appears to be backed up by Apaf -1-independent death systems.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
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Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.