Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Type I interferon signalling in the intestinal epithelium affects Paneth cells, microbial ecology and epithelial regeneration
Markus Tschurtschenthaler,Jun Wang,Cornelia Fricke,Teresa M.J. Fritz,Lukas Niederreiter,Timon E. Adolph,Edina Sarcevic,Sven Künzel,Felix Offner,Ulrich Kalinke,John F. Baines,Herbert Tilg,Arthur Kaser +12 more
TL;DR: IFNAR1 in IECs, and Paneth cells in particular, contributes to the regulation of the host–microbiota relationship, with consequences for intestinal regeneration and colitis-associated tumour formation.
Journal ArticleDOI
Type I IFN Negatively Regulates CD8+ T Cell Responses through IL-10-Producing CD4+ T Regulatory 1 Cells
Nektarios Dikopoulos,Antonio Bertoletti,Andrea Kröger,Hansjörg Hauser,Reinhold Schirmbeck,Jörg Reimann +5 more
TL;DR: Vaccine-induced, antiviral CD8+ T cell responses in IFN-β or type I IFN receptor-deficient mice are used to study immunomodulating effects of type IIFN that are not complicated by the interference of a concomitant virus infection.
Journal ArticleDOI
Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon‐I‐dependent manner in mice
Philipp A. Lang,Philipp A. Lang,Mike Recher,Nadine Honke,Stefanie Scheu,Stephanie Borkens,Nicole Gailus,Caroline Krings,Andreas Meryk,Andreas Kulawik,Luisa Cervantes-Barragan,Nico van Rooijen,Ulrich Kalinke,Burkhard Ludewig,Hans Hengartner,Nicola L. Harris,Dieter Häussinger,Pamela S. Ohashi,Rolf M. Zinkernagel,Karl S. Lang,Karl S. Lang +20 more
TL;DR: Tissue‐resident macrophages play a crucial role in early viral capture and represent the major liver cell type exhibiting responsiveness to IFN‐I and providing control of viral replication.
Journal ArticleDOI
NF-κB-Mediated Inhibition of Apoptosis Is Required for Encephalomyocarditis Virus Virulence: a Mechanism of Resistance in p50 Knockout Mice
Edward M. Schwarz,Cornel Badorff,Timothy S. Hiura,Rainer Wessely,Annette Badorff,Inder M. Verma,Kirk U. Knowlton +6 more
TL;DR: The attenuation in p50 −/− mice can be explained by rapid apoptosis of infected cells which allows host phagocytes to clear infected cells before the viral burst leading to a reduction of the viral burden and survival of the mice.
Journal ArticleDOI
Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling
Kylie M. Quinn,Daniel E. Zak,Andreia Costa,Ayako Yamamoto,Kathrin Kastenmüller,Brenna J. Hill,Geoffrey M. Lynn,Patricia A. Darrah,Ross W. B. Lindsay,Lingshu Wang,Cheng Cheng,Alfredo Nicosia,Antonella Folgori,Stefano Colloca,Riccardo Cortese,Emma Gostick,David Price,Jason G. D. Gall,Mario Roederer,Alan Aderem,Robert A. Seder +20 more
TL;DR: The findings reveal that the magnitude of rAd-induced memory CD8 T cell immune responses correlates with Ag expression but is independent of IFN and STING and provide criteria for optimizing protective CD8T cell immunity with rAd vaccines.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.