Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Journal ArticleDOI
Bugs in the system.
TL;DR: New and refined systems‐based approaches used to model, identify, and validate novel targets within complex networks following influenza and coronavirus infection are described and avenues for extension and expansion are proposed.
Journal ArticleDOI
Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency
Paul Bastard,Jeremy Manry,Jie Chen,Jérémie Rosain,Yoann Seeleuthner,Omar AbuZaitun,Lazaro Lorenzo,Taushif Khan,Mary Hasek,Nicholas Hernandez,Benedetta Bigio,Peng Zhang,Romain Lévy,Shai Shrot,Eduardo J. Garcia Reino,Yoon-Seung Lee,Soraya Boucherit,Mélodie Aubart,Rik Gijsbers,Vivien Béziat,Zhi Li,Sandra Pellegrini,Flore Rozenberg,Nico Marr,Isabelle Meyts,Bertrand Boisson,Aurélie Cobat,Jacinta Bustamante,Qian Zhang,Emmanuelle Jouangy,Laurent Abel,Raz Somech,Jean-Laurent Casanova,Shen-Ying Zhang +33 more
TL;DR: It is indicated that IFN-α/β are essential for anti-HSV-1 immunity in the CNS.
Book ChapterDOI
Pathogenic viruses: smart manipulators of the interferon system.
Otto Haller,Friedemann Weber +1 more
TL;DR: Current knowledge in light of most recent findings on the intricate interactions of viruses with the IFN system are summarized.
Journal ArticleDOI
Interferon-β expressed by a rabies virus-based HIV-1 vaccine vector serves as a molecular adjuvant and decreases pathogenicity
TL;DR: The use of interferon-beta to adjuvant the response to a rabies virus (RV) vaccine vector expressing both HIV-1 Gag and IFN-beta is explored and it is demonstrated that the expression of IFn-beta reduces viral replication approximately 100-fold.
Journal ArticleDOI
Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance
Tatsuaki Mizutani,Nina Neugebauer,Eva Maria Putz,Nadine Moritz,Olivia Simma,Eva Zebedin-Brandl,Dagmar Gotthardt,Wolfgang Warsch,Eva Eckelhart,Hans-Peter Kantner,Ulrich Kalinke,Stefan Lienenklaus,Siegfried Weiss,Birgit Strobl,Mathias Müller,Veronika Sexl,Dagmar Stoiber +16 more
TL;DR: The data reveal that despite the necessity for Type I IFN in NK cell maturation the expression of IFNAR1 on mature murine NK cells is not required for efficient tumor surveillance.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.