Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Book ChapterDOI
Cytokines and STAT signaling.
TL;DR: Signal transducers and activators of transcription (STATs) represent a family of conserved proteins, seven of which have been identified in mammals, and are now known to play a significant role in signal transduction for most cytokines.
Journal ArticleDOI
Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif
TL;DR: Functional participation of slfn8 in the regulatory networks governing T cell development and growth appears to be cell type specific.
Journal ArticleDOI
Expression of the Nitric Oxide Synthase 2 Gene Is Not Essential for Early Control of Mycobacterium tuberculosis in the Murine Lung
TL;DR: The role of nitric oxide in controlling Mycobacterium tuberculosis in the lung is investigated using a low-dose aerosol-mediated infection model in the mouse and it is found that while IFN-γ is pivotal in early control of bacterial growth in the lungs, this control does not completely depend upon the expression of the NOS2 gene.
Journal ArticleDOI
Natural Alpha Interferon-Producing Cells Respond to Human Immunodeficiency Virus Type 1 with Alpha Interferon Production and Maturation into Dendritic Cells
Akihito Yonezawa,Rimpei Morita,Akifumi Takaori-Kondo,Norimitsu Kadowaki,Toshio Kitawaki,Toshiyuki Hori,Takashi Uchiyama +6 more
TL;DR: It is suggested that IPC can directly recognize and respond to HIV-1 with IFN-α production, which is crucial for preventing progress of HIV- 1 infection and occurrence of opportunistic infection.
Journal ArticleDOI
Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors.
Kenji Oritani,Kay L. Medina,Yoshiaki Tomiyama,Jun Ishikawa,Yu Okajima,Megumu Ogawa,Takahumi Yokota,Keisuke Aoyama,Isao Takahashi,Paul W. Kincade,Yuji Matsuzawa +10 more
TL;DR: An interferon-like cytokine, limitin, is identified on the basis of its ability to arrest the growth of or kill lympho–hematopoietic cells and may represent a previously unknown type I interferons prototype.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.