Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Journal ArticleDOI
Identification of Host Cytosolic Sensors and Bacterial Factors Regulating the Type I Interferon Response to Legionella pneumophila
TL;DR: The results provide new insights into the molecular mechanisms by which an intracellular bacterial pathogen activates and also represses innate immune responses and a secreted effector protein, SdhA, is identified as a key suppressor of the IFN response to L. pneumophila.
Journal ArticleDOI
Modulation of the non-specific defence of fish by structurally conserved microbial polymers
TL;DR: Several lines of evidence suggest that the NSD has evolved towards recognition of structurally conserved microbial polymers like fungal cell wall β-glucans, bacterial LPS and peptidoglycan, bacterial DNA and viral double-stranded RNA (dsRNA).
Journal ArticleDOI
Natural type I interferon-producing cells as a link between innate and adaptive immunity.
Norimitsu Kadowaki,Yong-Jun Liu +1 more
TL;DR: The remarkable versatility of plasmacytoid pre-DCs distinguishes them from other cell types in the immune system that have only limited functions, and suggests that these cells may play a key role in integrating the innate and adaptive aspects of various immune responses.
Journal ArticleDOI
Theiler"s virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors
L. Fiette,Corinne Aubert,U. Muller,Sui Huang,Michel Aguet,Michel Brahic,Jean-François Bureau +6 more
TL;DR: The results show that the two interferon systems play nonredundant roles in the resistance of the 129Sv mouse to the infection by Theiler's virus, and lend support to the notion that the Ifg gene is involved in the Resistance/susceptibility of inbred strains of mice to persistent infection by this picornavirus.
Journal ArticleDOI
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Nagaraj Kerur,Nagaraj Kerur,Shinichi Fukuda,Shinichi Fukuda,Daipayan Banerjee,Daipayan Banerjee,Younghee Kim,Younghee Kim,Dongxu Fu,Ivana Apicella,Akhil Varshney,Reo Yasuma,Reo Yasuma,Benjamin J. Fowler,Elmira Baghdasaryan,Kenneth M. Marion,Xiwen Huang,Tetsuhiro Yasuma,Tetsuhiro Yasuma,Yoshio Hirano,Yoshio Hirano,Vlad Serbulea,Meenakshi Ambati,Vidya L. Ambati,Yuji Kajiwara,Kameshwari Ambati,Kameshwari Ambati,Shuichiro Hirahara,Ana Bastos-Carvalho,Yuichiro Ogura,Hiroko Terasaki,Tetsuro Oshika,Kyung Bo Kim,David R. Hinton,Norbert Leitinger,John C. Cambier,Joseph D. Buxbaum,M. Cristina Kenney,S. Michal Jazwinski,Hiroshi Nagai,Isao Hara,A. Phillip West,Katherine A. Fitzgerald,Srinivas R. Sadda,Bradley D. Gelfand,Jayakrishna Ambati +45 more
TL;DR: It is demonstrated that RPE degeneration in human-cell-culture and mouse models is driven by a noncanonical-inflammasome pathway that activates caspase-4, gasdermin D, interferon-β, and cGAS levels were elevated in the RPE in human eyes with geographic atrophy, and an unexpected role of cGas in responding to mobile-element transcripts is highlighted.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.