Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing.
Marie Pourcelot,Marie Pourcelot,Naima Zemirli,Naima Zemirli,Leandro Silva da Costa,Leandro Silva da Costa,Roxane Loyant,Roxane Loyant,Dominique Garcin,Damien Vitour,Ivana Munitic,Aimé Vazquez,Aimé Vazquez,Damien Arnoult,Damien Arnoult +14 more
TL;DR: An unexpected role of the Golgi apparatus in innate immunity as a key subcellular gateway for TBK1 activation after RNA virus infection is highlighted.
Journal ArticleDOI
Antiviral B Cell Memory in the Absence of Mature Follicular Dendritic Cell Networks and Classical Germinal Centers in TNFR1−/− Mice
Urs Karrer,Constantino López-Macías,Annette Oxenius,Bernhard Odermatt,Martin F. Bachmann,Ulrich Kalinke,Horst Bluethmann,Hans Hengartner,Rolf M. Zinkernagel +8 more
TL;DR: Increased Ag dose and time of Ag availability can substitute for FDC-stored Ab-complexed Ag in the induction of efficient IgG responses in TNFR1−/− mice devoid of classical germinal centers.
Journal ArticleDOI
Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection.
Masa Ivin,Amy Dumigan,Filipe Nuno Vasconcelos,Florian Ebner,Martina Borroni,Anoop Kavirayani,Kornelia Przybyszewska,Rebecca J. Ingram,Stefan Lienenklaus,Ulrich Kalinke,Dagmar Stoiber,José A. Bengoechea,Pavel Kovarik +12 more
TL;DR: It is shown that type I interferon (IFN) signaling protects against lung infection with K. pneumoniae by launching bacterial growth-controlling interactions between alveolar macrophages and natural killer (NK) cells.
Journal ArticleDOI
Effectiveness of interferon-alpha therapy in chronic hepatitis C is associated with the amount of interferon-alpha receptor mRNA in the liver
Ryo Fukuda,Norihisa Ishimura,Yoshinori Kushiyama,Nobuyuki Moriyama,Shunji Ishihara,Sachiko Nagasawa,Tatsuya Miyake,Misa Niigaki,Shuichi Satoh,Shino Sakai,Shuji Akagi,Makoto Watanabe,Shiro Fukumoto +12 more
TL;DR: The results suggest that the amount ofinterferon-alpha receptor mRNA is an important factor determining the response to interferon, and may be a new predictor of interferons response in chronic hepatitis C.
Journal ArticleDOI
Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types.
Elena Tomasello,Elena Tomasello,Elena Tomasello,Emeline Pollet,Emeline Pollet,Emeline Pollet,Thien-Phong Vu Manh,Thien-Phong Vu Manh,Thien-Phong Vu Manh,Gilles Uzé,Marc Dalod,Marc Dalod,Marc Dalod +12 more
TL;DR: This work discusses how induction or blockade of specific IFN-I responses in targeted cell types could promote the beneficial functions of IFn-I and/or dampen their deleterious effects, in a manner adapted to each disease.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.