Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis.
Reza Khorooshi,Marlene Thorsen Mørch,Thomas Hellesøe Holm,Thomas Hellesøe Holm,Carsten Tue Berg,Ruthe Storgaard Dieu,Dina Dræby,Shohreh Issazadeh-Navikas,Siegfried Weiss,Stefan Lienenklaus,Trevor Owens +10 more
TL;DR: Results show that Type IIFN induced within the CNS can play a protective role in EAE and highlight the role of endogenous type I IFN in mediating neuroprotection.
Journal ArticleDOI
Effects of Type I Interferons on Friend Retrovirus Infection
TL;DR: Findings indicate that type I IFN plays an important role in the immediate antiviral defense against Friend retrovirus infection.
Journal ArticleDOI
Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection.
J. Judy Chang,Aurore Lacas,Robert J. Lindsay,Erin Doyle,Karen L. Axten,Florencia Pereyra,Eric S. Rosenberg,Bruce D. Walker,Todd M. Allen,Marcus Altfeld +9 more
TL;DR: Responsiveness to TLR7/8 stimulation, which have been shown to recognize HIV-1 ssRNA, did not decrease in chronic infection, and may represent a contributing factor to ongoing T-cell immune activation in the setting of chronic viremic HIV- 1 infection.
Journal ArticleDOI
Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type i interferon receptor, ifnar 2
Catherine M Owczarek,Seung Y. Hwang,Kerry A. Holland,Lerna Gulluyan,Michael Tavaria,Brian K. Weaver,Nancy C. Reich,Ismail Kola,Paul J. Hertzog +8 more
TL;DR: It is demonstrated that the IFNAR 2 transmembrane (2c) and soluble (2a) isoforms are conserved between the human and mouse and that IFnAR 2c has intrinsic ligand binding activity, but no intrinsic signal transducing activity as measured in this study.
Journal ArticleDOI
IFN-α/β Receptor Signaling Promotes Regulatory T Cell Development and Function under Stress Conditions
Amina Metidji,Sadiye Amcaoglu Rieder,Deborah D. Glass,Isabelle Cremer,George A. Punkosdy,Ethan M. Shevach +5 more
TL;DR: In mixed chimeras between wild-type and IFN-α/β receptor (IFNAR) knockout mice, Tregs derived from IFNAR KO bone marrow were unable to control T effector cell activation and tissue inflammation and may be required to maintain Treg homeostasis and function.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.