Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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How Viral and Intracellular Bacterial Pathogens Reprogram the Metabolism of Host Cells to Allow Their Intracellular Replication.
TL;DR: This review compares the present knowledge on this important, yet still poorly understood aspect of pathogenesis of human viral and especially IBP infections with that oncogenes and tumor suppressors.
Journal ArticleDOI
A target on the move: innate and adaptive immune escape strategies of hepatitis C virus.
TL;DR: The current state of research regarding innate and adaptive immune responses against HCV and the different escape strategies evolved by this virus are summarized.
Journal ArticleDOI
Effective Innate and Adaptive Antimelanoma Immunity through Localized TLR7/8 Activation
Manisha Singh,Hiep Khong,Zhimin Dai,Xue Fei Huang,Jennifer A. Wargo,Zachary A. Cooper,John P. Vasilakos,Patrick Hwu,Willem W. Overwijk +8 more
TL;DR: Intratumoral treatment with 3M-052 is a promising approach for the treatment of cancer and a rational strategy and mechanistic understanding is established for combination therapy with intratumoral, tissue-retained TLR7/8 agonist and checkpoint blockade in metastatic cancer.
Journal ArticleDOI
Innate immunity and HCV
TL;DR: Recent genetic variations near the IL28B were found to be strongly associated with spontaneous clearance of HCV and response to treatment with PegIFN-α and ribavirin, which supports a central role of the innate immune response in host-viral interactions.
Journal ArticleDOI
Evaluation of Antiviral Efficacy of Ribavirin, Arbidol, and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever
Lisa Oestereich,Toni Rieger,Melanie Neumann,Christian Bernreuther,Maria Lehmann,Susanne Krasemann,Stephanie Wurr,Petra Emmerich,Xavier de Lamballerie,Stephan Ölschläger,Stephan Günther +10 more
TL;DR: Activated hepatic macrophages and monocyte-derived cells may play a role in the proinflammatory cytokine response in CCHF and its in vivo efficacy exceeds that of the current standard drug for treatment of C CHF, ribavirin.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.