Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Creation and characterization of a recombinant mammalian orthoreovirus expressing human epidermal growth factor receptor 2 peptides
TL;DR: S1/HER2nhd as discussed by the authors is a recombinant MRV that can induce HER2 specific CD8+ and CD4+ T cells in infected cells and on the virion, and infects, replicates and reduces HER2+ breast cancer cell survival.
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Pteropine orthoreoviruses use cell surface heparan sulphate as an attachment receptor
Lin-Fa Wang,Andrew Treglown +1 more
TL;DR: In this article , the role of heparan sulphate (HS) as an attachment receptor for pteropine orthoreovirus (PRV) infection was investigated.
Developmental expression pattern of junctional adhesion molecule-a (jam-a)
TL;DR: JAM-A is prominently expressed in embryonic vasculature and the epithelial components of several organ systems as well as the epithelium of the developing skin, olfactory system, lungs, and kidneys.
Strategies to Improve Adenovirus and Reovirus Vectors for Oncolytic Virotherapy
TL;DR: Modification of capsid proteins can change the cell tropisms and these modifications may provide more insight into the function of the Capsid proteins in adenovirus and reovirus vectors, which may reflect the clinical variation.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.