Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
Citations
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Journal ArticleDOI
Generation of Genetically RGD σ1-Modified Oncolytic Reovirus That Enhances JAM-A-Independent Infection of Tumor Cells.
Takahiro Kawagishi,Yuta Kanai,Ryotaro Nouda,Ichika Fukui,Jeffery A. Nurdin,Yoshiharu Matsuura,Takeshi Kobayashi +6 more
TL;DR: A reverse genetic approach was used to introduce an integrin-affinity peptide sequence into the MRV cell attachment protein σ1 to alter the natural tropism of the virus, and developed a reverse genetics system for MRV strain T3D-L, which showed high oncolytic potency.
Journal ArticleDOI
A comparative molecular force spectroscopy study of homophilic JAM-A interactions and JAM-A interactions with reovirus attachment protein sigma1.
Sri Ram Krishna Vedula,Tong Seng Lim,Eva Kirchner,Kristen M. Guglielmi,Terence S. Dermody,Thilo Stehle,Thilo Stehle,Walter Hunziker,Chwee Teck Lim +8 more
TL;DR: A short bond lifetime imparts a highly dynamic nature to homophilic JAM‐A interactions for regulating tight junction permeability while stable interactions between σ1 and JAM•A likely anchor the virus to the cell surface and facilitate viral entry.
Book ChapterDOI
Targeting Norovirus: Strategies for the Discovery of New Antiviral Drugs
TL;DR: Viruses are responsible for the majority of cases of gastroenteritis with rotaviruses and noroviruses being the major pathogens.
Dissertation
Développement de procédés efficaces pour la construction et la production de vecteurs adénoviraux
TL;DR: The goal of this thesis was to design a new transfer vector in which the PS expression was independent from the expression of the transgene in order to be able to optimize its expression independently.
Journal ArticleDOI
The Biology of Endothelial Cell–Cell Lateral Junctions
TL;DR: This issue of Microcirculation explored mechanisms of paracellular and transcellular permeability and whether one or both mechanisms predominate in pathophysiological conditions such as inflammation or tumor angiogenesis remains unresolved.
References
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Journal ArticleDOI
Selective extraction of polyoma DNA from infected mouse cell cultures.
Journal ArticleDOI
Activators and target genes of Rel/NF-kappaB transcription factors.
TL;DR: It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
Journal ArticleDOI
Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
Journal ArticleDOI
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
Journal ArticleDOI
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.