Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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The tight junction: a multifunctional complex.
TL;DR: A group of integral membrane proteins-occludin, claudins, and junction adhesion molecules-interact with an increasingly complex array of tight junction plaque proteins not only to regulate paracellular solute and water flux but also to integrate such diverse processes as gene transcription, tumor suppression, cell proliferation, and cell polarity.
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Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.
Matthew J. Evans,Thomas von Hahn,Donna M. Tscherne,Andrew J. Syder,Maryline Panis,Benno Wölk,Theodora Hatziioannou,Jane A. McKeating,Jane A. McKeating,Paul D. Bieniasz,Charles M. Rice +10 more
TL;DR: Using an iterative expression cloning approach, claudin-1 (CLDN1), a tight junction component that is highly expressed in the liver, is identified as essential for HCV entry and a new target for antiviral drug development.
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Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis
TL;DR: How the molecular architectures and interactions may represent a mechanistic basis for the function and regulation of junctions, focusing on junction assembly and permeability regulation, is emphasized.
Journal ArticleDOI
Tight junction proteins.
TL;DR: Advances in the knowledge of the molecular structure of TJ support previous physiological models that exhibited TJ as dynamic structures that present distinct permeability and morphological characteristics in different tissues and in response to changing natural, pathological or experimental conditions.
Journal ArticleDOI
Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms
Matthias Bruewer,Andreas Luegering,Andreas Luegering,Torsten Kucharzik,Torsten Kucharzik,Charles A. Parkos,James L. Madara,James L. Madara,Ann M. Hopkins,Asma Nusrat +9 more
TL;DR: These findings for the first time clearly separate the proapoptotic effects of IFN-γ and TNF-α from their abilities to disrupt barrier function.
References
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Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing).
TL;DR: Polyclonal and monoclonal antibodies protect mice from fatal infection with T3 after either footpad or intracerebral virus challenge and antibody mediated protection against this neurally spreading virus does not require neutralizing antibody or serum complement and occurs even in the face of established CNS infection.
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CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia
Charles A. Parkos,Scan P. Colgan,Tony W. Liang,Asma Nusrat,Abraham E. Bacarra,Denice K. Carnes,James L. Madara +6 more
TL;DR: Purification, microsequence analysis, and cross-blotting experiments indicate that the C5/D5 antigen represents CD47, a previously cloned integral membrane glycoprotein with homology to the immunoglobulin superfamily, which represents a potential new therapeutic target for downregulating active inflammatory disease of mucosal surfaces.
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Absolute Linkage of Virulence and Central Nervous System Cell Tropism of Reoviruses to Viral Hemagglutinin
TL;DR: It is shown that the hemagglutinin (HA) of reovirus, encoded in the S1 gene, determines the central nervous system (CNS) cell tropism ofReovirus type 1 and 3 was shown using recombinant clones containing nine genes from one serotype and the S 1 gene from the other.
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Utilization of sialic acid as a coreceptor enhances reovirus attachment by multistep adhesion strengthening.
TL;DR: Results indicate that reovirus binding to sialic acid enhances virus infection through adhesion of virus to the cell surface where access to a proteinaceous receptor is thermodynamically favored.
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Distinct pathways of viral spread in the host determined by reovirus S1 gene segment
TL;DR: The viral S1 double-stranded RNA segment was shown to be responsible for determining the capacity of reoviruses to spread to the central nervous system through these distinct pathways.