Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Going (Reo)Viral: Factors Promoting Successful Reoviral Oncolytic Infection.
TL;DR: This review will examine each of the factors that contribute to productive viral infections in cancerous cells versus healthy cells and speculate about potential new mechanisms that may enhance successful replication.
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Expression of HBX, an Oncoprotein of Hepatitis B Virus, Blocks Reoviral Oncolysis of Hepatocellular Carcinoma Cells
Eun Hee Park,Sang Seok Koh,Ratakorn Srisuttee,Il-Rae Cho,Hye-Jin Min,Byung Hak Jhun,Yangsoon Lee,K L Jang,C H Kim,Randal N. Johnston,Young-Hwa Chung +10 more
TL;DR: It is reported that HBX, an oncoprotein of HBV, can prevent reoviral oncolysis of hepatocellular carcinoma, suggesting there may be limits to the practical application of reovirus in the treatment of human cancers already expressing other oncoviral proteins.
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Tamiflu-resistant but HA-mediated cell-to-cell transmission through apical membranes of cell-associated influenza viruses.
TL;DR: It is demonstrated that influenza virus can utilize cell-to-cell transmission pathway through apical membranes, by handover of virions on the surface of an infected cell to adjacent host cells, leading to the caution that local infection proceeds even when treated with neuraminidase inhibitors.
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Reovirus Neurotropism and Virulence Are Dictated by Sequences in the Head Domain of the Viral Attachment Protein.
Danica M. Sutherland,Pavithra Aravamudhan,Pavithra Aravamudhan,Melanie H. Dietrich,Thilo Stehle,Terence S. Dermody,Terence S. Dermody +6 more
TL;DR: This work discovered that sequences forming the most virion-distal domain of T1 and T3 σ1 coordinate infection of either ependyma or neurons, respectively, leading to mutually exclusive patterns of tropism and disease in the central nervous system (CNS).
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The F11 Receptor (F11R)/Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A) in cancer progression.
TL;DR: The F11 Receptor (F11R) as discussed by the authors is a transmembrane glycoprotein of the immunoglobulin superfamily, which is mainly located in epithelial and endothelial cell tight junctions and also expressed on circulating platelets and leukocytes.
References
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
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TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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