Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Journal ArticleDOI
Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy
TL;DR: The investigation revealed that HDAC inhibitor-resistant cells displayed enhanced vulnerability to reovirus replication and cell death in both in vitro and in vivo models compared with their parental counterparts, and Reolysin also significantly increased the antilymphoma activity of belinostat in HDAC inhibitors- resistant cells.
Book ChapterDOI
An Orchestra of Reovirus Receptors: Still Searching for the Conductor.
TL;DR: The state of the reovirus receptor field is summarized and open questions toward understanding how the reOVirus attachment protein dictates CNS tropism are discussed.
Journal ArticleDOI
Baculovirus-assisted Reovirus Infection in Monolayer and Spheroid Cultures of Glioma cells
Iris J. C. Dautzenberg,Sanne K. van den Hengel,Jeroen de Vrij,Lars Ravesloot,Steve J. Cramer,Saw-See Hong,Diana J. M. van den Wollenberg,Pierre Boulanger,Rob C. Hoeben +8 more
TL;DR: The identification of baculovirus’ capacity to penetrate into tumour tissue opens novel opportunities to improve cancer therapy by improved delivery of oncolytic viruses into tumours.
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Porcine rotavirus mainly infects primary porcine enterocytes at the basolateral surface
TL;DR: In this paper, the role of intestinal epithelial integrity was examined in the presence of rotavirus infection in primary colon cells, and it was shown that integrity of the intestinal epithelium is crucial in the host's innate defense.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.