Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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The Reovirus σ1 Attachment Protein Influences the Stability of Its Entry Intermediate
TL;DR: In this paper , the authors studied the effect of the attachment protein of the reovirus σ1 attachment protein on the stability of the infectious sub-virus particle (ISVP).
DissertationDOI
Examination of viral infection and host response to define therapeutic potential of oncolytic mammalian orthoreovirus
TL;DR: Novel HIF-1α inhibitors are being investigated for safety and efficacy to inhibit these effects, as well as to sensitize hypoxic tumors to current cancer therapies, while viruses are not often thought of as therapies.
Posted ContentDOI
An unusual aspartic acid cluster in the reovirus attachment fiber σ1 mediates stability at low pH
TL;DR: This article showed that all domains of the reovirus attachment protein Sigma1 are remarkably thermostable across a wide range of pH, even at the low pH of the stomach Interestingly, they determined the optimal pH for stability to be between pH 5-6, a value close to the pH of endosome and of the jejunum.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
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TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
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