Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Journal ArticleDOI
Mechanisms of Cell Entry by dsRNA Viruses: Insights for Efficient Delivery of dsRNA and Tools for Improved RNAi-Based Pest Control.
TL;DR: In this paper, the mechanism of cell entry by dsRNA viruses belonging to the Reoviridae family is discussed in detail, which can be incorporated into the design of DsRNA virus-based viral-like particles for optimal delivery of RNAi triggers in targeted insect pests.
Book ChapterDOI
15 – Pathogenic mechanisms of foodborne viral disease
B. B. Goswami,M. Kulka,M. Potter +2 more
Book ChapterDOI
JAM Family Proteins
Susumu Hirabayashi,Yutaka Hata +1 more
TL;DR: Junctional adhesion molecules (JAMs) are implicated in diverse biological functions at TJs, including cell-cell adhesion, junctional assembly, Junctional stabilization, regulation of paracellular permeability and leucocyte transmigration.
Posted ContentDOI
Breast tumor-associated metalloproteases restrict reovirus oncolysis by cleaving the σ1 cell-attachment protein, and can be overcome by mutation of σ1
Jason P Fernandes,Francisca Cristi,Heather E. Eaton,Patricia A. Chen,Sarah Haeflinger,Isabelle Bernard,Mary M. Hitt,Maya Shmulevitz +7 more
TL;DR: It is demonstrated that metalloproteases in breast tumor microenvironments can inactivate reov virus, exposing that tumor microenvironment proteases could have negative impact on proteinaceous cancer therapies such as reovirus, and that modification of such therapies to circumvent inactivation by tumor metalliproteases merits consideration.
Journal ArticleDOI
Loss of sialic acid binding domain redirects protein σ1 to enhance M cell-directed vaccination.
Dagmara Złotkowska,Massimo Maddaloni,Carol Riccardi,Nancy Walters,Kathryn Holderness,Gayle Callis,Agnieszka Rynda-Apple,David W. Pascual +7 more
TL;DR: It is shown that pσ1(s) can be fused to vaccines to effectively elicit improved SIgA responses and was more efficient for immunization than native OVA+CT.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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