Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Aedes aegypti lachesin protein binds to the domain III of envelop protein of Dengue virus-2 and inhibits viral replication.
Vipin Singh Rana,Vipin Singh Rana,Sonam Popli,Sonam Popli,Gunjan Kumar Saurav,Karuna Yadav,Ankit Kumar,Sujatha Sunil,Narendra Kumar,Om P. Singh,Krishnamurthy Natarajan,Raman Rajagopal +11 more
TL;DR: Blocking of lachesin protein in Ae.
Book ChapterDOI
Genetic Modification in Mammalian Orthoreoviruses
Sanne K. van den Hengel,Sanne K. van den Hengel,Iris J. C. Dautzenberg,Diana J. M. van den Wollenberg,Peter A. E. Sillevis Smitt,Rob C. Hoeben +5 more
Journal ArticleDOI
The use of immunohistochemistry to determine oncolytic reovirus distribution and replication in-human tumors.
Roxna Kapadia,Matthew C. Coffey +1 more
TL;DR: An overview of the development of REOLYSIN as a potential cancer therapeutic and the growing role of in situ based molecular pathology methods in providing clinical proof of concept and in guiding clinical development is provided.
Journal ArticleDOI
Reovirus mutant jin-3 exhibits lytic and immune-stimulatory effects in preclinical human prostate cancer models
Arjanneke F. van de Merbel,Geertje van der Horst,Maaike H. van der Mark,Selas T F Bots,Diana J. M. van den Wollenberg,Corrina M.A. de Ridder,Debra Stuurman,Tilly Aalders,Sigrun Erkens-Schulz,Nadine van Montfoort,Wouter R. Karthaus,Niven Mehra,Minke Smits,Jack A. Schalken,Wytske M. van Weerden,Rob C. Hoeben,Gabri van der Pluijm +16 more
TL;DR: In this article, the authors evaluated the oncolytic efficacy of the bioselected reovirus mutant jin-3 in multiple human prostate cancer models, and showed that the revirus mutant exhibited efficient infection, replication, and anti-cancer responses in two-dimensional and three-dimensional (2D and 3D) prostate cancer.
Journal ArticleDOI
Reovirus: Friend and Foe.
TL;DR: Using mouse models of CeD, reovirus caused loss of oral tolerance to dietary antigens, opening the possibility thatReovirus could trigger CeD in humans, and new developments in reoviral oncolysis and studies suggesting a role for reov virus as a trigger for celiac disease are focused on.
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