Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Polymorphisms in the most oncolytic reovirus strain confer enhanced cell attachment, transcription and single-step replication kinetics.
TL;DR: Why the most oncolytic T3D reovirus lab strain, the Patrick Lee laboratory strain (T3DPL), replicates more efficiently in cancer cells than other commonly used laboratory strains, the Kevin Coombs laboratory strain(T3DKC) and Terence Dermody laboratory (T2DTD) strain is determined.
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Adenovirus infection: taking the back roads to viral entry.
Danika L Goosney,Glen R. Nemerow +1 more
TL;DR: Certain virus receptors are sequestered on the basolateral surface of polarized epithelial cells and adenovirus--and perhaps other viruses--are able to overcome this physical barrier.
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Early Porcine Sapovirus Infection Disrupts Tight Junctions and Uses Occludin as a Coreceptor.
Mia Madel Alfajaro,Eun-Hyo Cho,Deok-Song Kim,Ji-Yun Kim,Jun-Gyu Park,Mahmoud Soliman,Yeong-Bin Baek,Chul-Ho Park,Mun-Il Kang,Sang-Ik Park,Kyoung-Oh Cho +10 more
TL;DR: It is found that porcine sapovirus (PSaV) significantly decreased transepithelial electrical resistance and increased paracellular permeability early in infection of LLC-PK cells, suggesting that PSaV dissociates TJs of cells.
Journal ArticleDOI
Cloning and preliminary functional studies of the JAM-A gene in grass carp (Ctenopharyngodon idellus).
TL;DR: The cloned and elucidated the structure of the JAM-A gene in grass carp (GcJ AM-A), and the expression of genes involved in the interferon and apoptosis pathways was significantly inhibited, suggesting that GcJAM- A could be a receptor for GCRV.
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Efficacy of oncolytic reovirus against human gastric cancer with peritoneal metastasis in experimental animal model
Koji Kawaguchi,Tsuyoshi Etoh,Kosuke Suzuki,Marcelo Takahiro Mitui,Akira Nishizono,Norio Shiraishi,Seigo Kitano +6 more
TL;DR: In conclusions, intraperitoneal administration of reovirus could be useful as a new modality against peritoneal metastasis in gastric cancer.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
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