Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Clathrin adaptor AP1B controls adenovirus infectivity of epithelial cells
Fernando Diaz,Diego Gravotta,Ami A. Deora,Ryan Schreiner,John W. Schoggins,Erik Falck-Pedersen,Enrique Rodriguez-Boulan +6 more
TL;DR: The cellular machinery responsible for normal sorting of an adenovirus receptor is characterized and how tissue-specific variations in such machinery result in drastic changes in tissue-susceptibility toadenoviruses is illustrated.
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Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun.
TL;DR: A significant correlation between the capacity of T1L × T3D reassortant reoviruses to both activate JNK and phosphorylate c-Jun and to induce apoptosis was shown.
Journal ArticleDOI
The Nogo Receptor NgR1 Mediates Infection by Mammalian Reovirus
Jennifer L. Konopka-Anstadt,Bernardo A. Mainou,Danica M. Sutherland,Yuichi Sekine,Stephen M. Strittmatter,Terence S. Dermody +5 more
TL;DR: It is demonstrated that reovirus binds Nogo receptor NgR1, a leucine-rich repeat protein expressed in the CNS, to infect neurons, and suggests thatReovirus uses different capsid components to bind distinct cell-surface molecules, engaging independent receptors to facilitate spread and tropism.
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5-HT2 Receptors Facilitate JC Polyomavirus Entry
Benedetta Assetta,Melissa S. Maginnis,Irene Gracia Ahufinger,Sheila A. Haley,Gretchen V. Gee,Christian D. S. Nelson,Bethany A. O'Hara,Stacy-ann A. Allen Ramdial,Walter J. Atwood +8 more
TL;DR: To define the roles of serotonin receptors in infection, HEK293A cells, which are poorly permissive to JCPyV, were transfected with 14 different isoforms of serotonin receptor and data confirm that the carbohydrate LSTc is the attachment receptor for JCPYV and that the type 2 serotonin receptors contribute to J CPyV infection by facilitating entry.
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Advances in nasal drug delivery through tight junction technology.
Paul H. Johnson,Steven C. Quay +1 more
TL;DR: Experimental and statistical methodologies used for the identification of new classes of TJ modulators are described, which are capable of reversibly opening TJ barriers with broad potential to significantly improve intranasal and, eventually, oral drug delivery.
References
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Selective extraction of polyoma DNA from infected mouse cell cultures.
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Activators and target genes of Rel/NF-kappaB transcription factors.
TL;DR: It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.