Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease
Erik S. Barton,Bryan E. Youree,Daniel H. Ebert,J. Craig Forrest,Jodi L. Connolly,Tibor Valyi-Nagy,Tibor Valyi-Nagy,Kay Washington,J. Denise Wetzel,Terence S. Dermody +9 more
TL;DR: It is suggested that the carbohydrate-binding specificity of a virus can dramatically alter disease in the host and highlight the need for epidemiologic studies focusing on infection by sialic acid-binding reovirus strains as a possible contributor to the pathogenesis of neonatal biliary atresia.
Journal ArticleDOI
ICAM-1: targeted docking for exogenous as well as endogenous ligands
TL;DR: More novel aspects of epithelial ICAM-1 expression are dealt with, particularly its induction upon apical epithelial surfaces and the potential functional consequences for both pathogen invasion and host defence.
Journal ArticleDOI
A novel interface consisting of homologous immunoglobulin superfamily members with multiple functions
Zhuwei Xu,Boquan Jin +1 more
TL;DR: The findings that CD155/poliovirus receptor (PVR) and CD112/nectin-2 are the ligands for CD226/platelet and T-cell activation antigen 1 (PTA1)/DNAX accessory molecular-1 (DNAM-1), CD96/tactile and Washington University cell adhesion molecule (WUCAM) have largely expanded knowledge about the functions of CD226, CD96, WUCAM and LFA-1.
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Isolation and Molecular Characterization of a Novel Type 3 Reovirus from a Child with Meningitis
Kenneth L. Tyler,Erik S. Barton,Maria L. Ibach,Christine Robinson,Christine Robinson,Jacquelyn A. Campbell,Sean M. O'Donnell,Tibor Valyi-Nagy,Penny Clarke,Penny Clarke,J. Denise Wetzel,Terence S. Dermody +11 more
TL;DR: Results suggest that serotype 3 reoviruses can cause meningitis in humans, and T3C/96 is capable of systemic spread in newborn mice after peroral inoculation and produces lethal encephalitis.
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Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein
Hao Song,Zhennan Zhao,Yan Chai,Xiyue Jin,Changyao Li,Fei Yuan,Sheng Liu,Sheng Liu,Zhengrong Gao,Haiyuan Wang,Jian Song,Leonardo Vazquez,Yanfang Zhang,Shuguang Tan,Carlos M. Morel,Jinghua Yan,Yi Shi,Jianxun Qi,Feng Gao,George F. Gao +19 more
TL;DR: The atomic details at the interface between the two binding entities reveal that both the two domains and the hinge region of MXRA8 are involved in interaction with CHIKV E1-E2 residues from two protomers.
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