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Open AccessJournal ArticleDOI

Junction Adhesion Molecule Is a Receptor for Reovirus

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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.
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This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.

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Journal ArticleDOI

Structural Insights into Calicivirus Attachment and Uncoating

TL;DR: This study provides the first structural view of a native calicivirus-protein receptor complex and insights into the mechanisms of virus attachment and uncoating.
Journal ArticleDOI

Sequence Analysis of the Genome of Piscine Orthoreovirus (PRV) Associated with Heart and Skeletal Muscle Inflammation (HSMI) in Atlantic Salmon (Salmo salar)

TL;DR: Detailed sequence analysis of the PRV genome showed that many protein motifs or key amino acid residues known to be central to protein function are conserved for most PRV proteins, and it was concluded that PRV has more properties in common with orthoreoviruses than with aquareovirus.
Book ChapterDOI

Structural studies on adenoviruses.

TL;DR: This chapter reviews the information that structural biology techniques have provided about the adenovirus proteins and capsid and reveals a surprising similarity between adenvirus and a bacterial virus, which suggests their common evolutionary origin.
Journal ArticleDOI

Reovirus receptors and pathogenesis.

TL;DR: Mammalian reoviruses are nonenveloped viruses that contain a segmented double-stranded RNA genome that serve as hosts for reov virus infection, but reovirus-induced disease is restricted to the very young.
Journal ArticleDOI

Avian Reoviruses Cause Apoptosis in Cultured Cells: Viral Uncoating, but Not Viral Gene Expression, Is Required for Apoptosis Induction

TL;DR: Evidence is presented that avian reovirus infection of cultured cells causes activation of the intracellular apoptotic program and that this activation takes place during an early stage of the viral life cycle, suggesting that apoptosis is triggered from within the infected cell by viral products generated after intraendosomal uncoating of parental reovirions.
References
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Journal ArticleDOI

Activators and target genes of Rel/NF-kappaB transcription factors.

TL;DR: It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
Journal ArticleDOI

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
Journal ArticleDOI

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
Journal ArticleDOI

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.
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