Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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A Mosaic Fiber Adenovirus Serotype 5 Vector Containing Reovirus σ1 and Adenovirus Serotype 3 Knob Fibers Increases Transduction in an Ovarian Cancer Ex vivo System via a Coxsackie and Adenovirus Receptor–Independent Pathway
Yuko Tsuruta,Larisa Pereboeva,Joel N. Glasgow,Daniel T. Rein,Daniel T. Rein,Yosuke Kawakami,Ronald D. Alvarez,Rodney P. Rocconi,Gene P. Siegal,Paul Dent,Paul B. Fisher,David T. Curiel +11 more
TL;DR: A new type of Ad5 vector with the novel tropism, possessing fibers from Ad3 and reovirus, which exhibits enhanced infectivity via CAR-independent pathway(s), which exhibitsEnhanced infectivity enhancement in ovarian cancer cells with low CAR expression.
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Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons.
Pavithra Aravamudhan,Pavithra Aravamudhan,Krishnan Raghunathan,Krishnan Raghunathan,Jennifer L. Konopka-Anstadt,Amrita Pathak,Danica M. Sutherland,Danica M. Sutherland,Bruce D. Carter,Terence S. Dermody,Terence S. Dermody +10 more
TL;DR: Mechanisms of reovirus neuronal entry and transport are defined and a foundation to identify common host factors used by neuroinvasive viruses is established.
Journal ArticleDOI
Crystallographic structure of the α-helical triple coiled-coil domain of avian reovirus S1133 fibre.
Pablo Guardado-Calvo,Gavin C. Fox,Antonio L. Llamas-Saiz,Mark J. van Raaij,Mark J. van Raaij +4 more
TL;DR: The structure of a major sigmaC fragment, a receptor-binding fragment comprising residues 117-326, reveals an alpha-helical triple coiled-coil connected to the previously solved structure by a zinc-ion-containing linker, which may act as a functionally important hinge.
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The Effect of Cell Cycle Synchronization on Tumor Sensitivity to Reovirus Oncolysis
Lucy Heinemann,Guy Simpson,Nicola E. Annels,Richard G. Vile,Alan Melcher,Robin Prestwich,Kevin J. Harrington,Hardev Pandha +7 more
TL;DR: The potential for increased sensitivity of tumor cells to oncolytic reovirus by altering the normal cell cycle using clinically available pharmacological agents was investigated and clinical evaluation of this approach is supported by the extensive experience, low cost, simple administration, and availability of hydroxyurea.
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Proteomic analysis of membrane proteins of vero cells: exploration of potential proteins responsible for virus entry.
TL;DR: The MP proteome of the Vero cells was investigated using a shotgun LC-MS/MS approach and seventeen proteins had been revealed to be virus receptor proteins, which may provide valuable information to increase understanding of virus infection of Vero Cells.
References
More filters
Journal ArticleDOI
Selective extraction of polyoma DNA from infected mouse cell cultures.
Journal ArticleDOI
Activators and target genes of Rel/NF-kappaB transcription factors.
TL;DR: It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
Journal ArticleDOI
Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
Journal ArticleDOI
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
Journal ArticleDOI
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.