Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Book ChapterDOI
From Touchdown to Transcription: The Reovirus Cell Entry Pathway
Pranav Danthi,Kristen M. Guglielmi,Kristen M. Guglielmi,Eva Kirchner,Bernardo A. Mainou,Thilo Stehle,Thilo Stehle,Terence S. Dermody +7 more
TL;DR: Mechanisms of reovirus cell entry and activation of innate immune response signaling pathways are focused on.
Journal ArticleDOI
Immunohistochemical detection of piscine reovirus (PRV) in hearts of Atlantic salmon coincide with the course of heart and skeletal muscle inflammation (HSMI)
TL;DR: Investigation of the presence of PRV antigens in heart tissue of Atlantic salmon and monitor the virus distribution in the heart during the disease development confirmed the association between PRV and HSMI, and strengthen the hypothesis ofPRV being the causative agent of HSMI.
Journal ArticleDOI
Animal cell invasion by a large nonenveloped virus: reovirus delivers the goods
Kartik Chandran,Max L. Nibert +1 more
TL;DR: Molecular mechanisms by which nonenveloped animal viruses penetrate a cellular membrane to invade the host cytoplasm remain less well characterized than those used by enveloped viruses.
Journal ArticleDOI
Internalization of Oncolytic Reovirus by Human Dendritic Cell Carriers Protects the Virus from Neutralization
Elizabeth Ilett,Montserrat Bárcena,Fiona Errington-Mais,Stephen Griffin,Kevin J. Harrington,Hardev Pandha,Matthew C. Coffey,Peter Selby,Ronald W. A. L. Limpens,Mieke Mommaas,Rob C. Hoeben,Richard G. Vile,Alan Melcher +12 more
TL;DR: The delivery of reovirus via DC could be a promising new approach offering the possibility of combining systemic viral therapy for metastatic disease with induction of an antitumor immune response.
Journal ArticleDOI
Junctional adhesion molecule-A participates in the formation of apico-basal polarity through different domains
Daniela Rehder,Sandra Iden,Ines Nasdala,Joachim Wegener,Maria-Katharina Meyer zu Brickwedde,Dietmar Vestweber,Dietmar Vestweber,Klaus Ebnet +7 more
TL;DR: It is demonstrated that downregulation of JAM-A impairs the ability of MDCK II cells to form cysts in a three-dimensional matrix indicating the requirement of Jam-A for the development of apico-basal polarity.
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