Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Virion Structure of Baboon Reovirus, a Fusogenic Orthoreovirus That Lacks an Adhesion Fiber
Xiaodong Yan,Kristin N. Parent,Russell P. Goodman,Russell P. Goodman,Jinghua Tang,Jingyun Shou,Max L. Nibert,Roy Duncan,Timothy S. Baker +8 more
TL;DR: It is concluded that the evolution of ortho- and aquareoviruses has included a series of discrete gains or losses of particular components, several of which cross taxonomic boundaries.
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Hunting Viral Receptors Using Haploid Cells
Sirika Pillay,Jan E. Carette +1 more
TL;DR: The most commonly employed methods for virus receptor discovery are discussed, specifically highlighting the use of forward genetic screens in human haploid cells and the discovery of the lysosomal proteins NPC1 and LAMP1 as intracellular receptors for Ebola virus and Lassa virus.
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CRTAM: A molecule involved in epithelial cell adhesion.
Erika Garay,Genaro Patino-Lopez,Socorro Islas,Lourdes Alarcón,Elsy Canche-Pool,Ricardo Valle-Rios,Oscar Medina-Contreras,Giovana Granados,Bibiana Chávez-Munguía,Eusebio Juaristi,Vianney Ortiz-Navarrete,Lorenza González-Mariscal +11 more
TL;DR: It is demonstrated for the first time, that CRTAM is expressed in epithelial cells along the lateral membrane and is important for early cell–cell contacts and cell–substrate interactions.
Journal ArticleDOI
Microbes and their products--physiological effects upon mammalian mucosa.
TL;DR: An array of host function alterations is mediated by microbial pathogens including inflammatory responses, secretory responses, alteration of host cytoskeleton, disruption of epithelial tight junctions and apoptosis, the signaling axes involved in these interactions are potential targets for therapeutic strategies against infectious microbes.
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Interleukin-6, desmosome and tight junction protein expression levels in reflux esophagitis-affected mucosa
Fei-Yue Li,Yan Li +1 more
TL;DR: Findings indicate that TJ proteins are highly expressed as an early molecular event involved in RE development, and that IL-6 is an inflammatory factor in this process.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
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TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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