Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Journal ArticleDOI
Reovirus-Mediated Cytotoxicity and Enhancement of Innate Immune Responses Against Acute Myeloid Leukemia
Kathryn Hall,Karen Scott,Ailsa Rose,Michael J R Desborough,Kevin J. Harrington,Hardev Pandha,Christopher Parrish,Richard G. Vile,Matthew C. Coffey,David T. Bowen,Fiona Errington-Mais,Alan Melcher +11 more
TL;DR: Reovirus-mediated activation of natural killer cells, within the context of peripheral blood mononuclear cells, stimulated their anti-leukemia response, with increased NK degranulation and IFNγ production and enhanced killing of AML targets.
Journal ArticleDOI
Reovirus μ1 Protein Affects Infectivity by Altering Virus-Receptor Interactions.
TL;DR: It is demonstrated that a reassortant virus that expresses the M2 gene-encoded μ1 protein derived from prototype strain T3D in an otherwise prototype T1L background (T1L/T3DM2) infects cells more efficiently than parental T1l, and a previously unknown relationship between two nonadjacent reovirus outer capsid proteins, σ1 and μ1 is revealed.
Book ChapterDOI
Structural basis of nonenveloped virus cell entry.
Journal ArticleDOI
Structural Insights into Reovirus σ1 Interactions with Two Neutralizing Antibodies.
Melanie H. Dietrich,Kristen M. Ogden,Sarah P. Katen,Kerstin Reiss,Danica M. Sutherland,Robert H. Carnahan,Matthew Goff,Tracy Cooper,Terence S. Dermody,Thilo Stehle +9 more
TL;DR: The results provide direct evidence for a structural rearrangement of σ1 during virion-to-ISVP conversion and contribute new information about the mechanisms of antibody-mediated neutralization of reovirus.
Journal ArticleDOI
Amino acids 78 and 79 of Mammalian Orthoreovirus protein µNS are necessary for stress granule localization, core protein λ2 interaction, and de novo virus replication
TL;DR: It is shown that while this mutant cannot support de novo viral replication, it is able to rescue replication following siRNA knockdown of μNS, suggesting that μNS association with SGs, λ2, or both play roles in MRV replication.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
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