Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Antibody Blockade of Junctional Adhesion Molecule-A in Rabbit Corneal Endothelial Tight Junctions Produces Corneal Swelling
TL;DR: Investigation of the expression and function of Junctional adhesion molecule-A in the corneal endothelium provides new evidence that JAM-A and its binding partner AF-6 are expressed in tight junctions of the corney endothelial barrier function and that J AM-A has a major role in maintaining the corNEal endothelial Barrier function.
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Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet.
Tomoko Yonezawa,Aiji Ohtsuka,Teruhito Yoshitaka,Shuichi Hirano,Hiroyuki Nomoto,Kiyotaka Yamamoto,Yoshifumi Ninomiya +6 more
TL;DR: The results suggest that limitrin is physically and functionally associated with the blood‐brain barrier, implying that this protein may be useful as a diagnostic tool of barrier integrity.
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Identification of Regions and Residues in Feline Junctional Adhesion Molecule Required for Feline Calicivirus Binding and Infection
TL;DR: It is found that all domains of fJAM-A were necessary to confer susceptibility to FCV infection, and surface expression of f JAM- A was not sufficient to permit FCV infections by all of the isolates the authors investigated.
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The role of epithelial tight junctions involved in pathogen infections
Ru-Yi Lu,Wan-Xi Yang,Yan-Jun Hu +2 more
TL;DR: The role of the epithelial TJs involved in various pathogen infections is surveyed, and TJ targeted therapeutic and pharmacological application prospects are extended.
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Development and in vitro validation of a targeted delivery vehicle for DNA vaccines
TL;DR: Results suggest that sigma1-NLS is a useful bifunctional targeting ligand suitable for enhancing DNA delivery and subsequent gene expression for both DNA vaccine applications and nonviral gene therapy.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.