Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Book ChapterDOI
Mechanisms of reovirus bloodstream dissemination.
TL;DR: Using a robust mouse model and a dynamic reverse genetics system, a viral receptor and a viral nonstructural protein that are essential for hematogenous reovirus dissemination are identified and shed light on how microbial pathogens invade the bloodstream to disseminate and cause disease in infected hosts.
Journal ArticleDOI
Inhibition of NF-κB activity and cFLIP expression contribute to viral-induced apoptosis
TL;DR: Results demonstrate that inhibition of stimulus-induced activation of NF-κB and the resulting decrease in cFLIP expression promote reovirus-induced apoptosis.
Journal ArticleDOI
Heterogeneous reovirus susceptibility in human glioblastoma stem-like cell cultures
S K van den Hengel,S K van den Hengel,Rutger K. Balvers,Iris J. C. Dautzenberg,D J M van den Wollenberg,Jenneke Kloezeman,Martine L.M. Lamfers,P A E Sillivis-Smit,Rob C. Hoeben +8 more
TL;DR: The data support the use of reovirus as an oncolytic agent in glioblastoma and show that the expression of the JAM-A receptor is not a major determinant ofReovirus sensitivity in 3D GSC cultures.
Journal ArticleDOI
Applications of imaging techniques to studies of epithelial tight junctions
TL;DR: This review discusses the application of techniques to discern the function, localization, and regulation of epithelial TJs based on examples from published studies.
Journal ArticleDOI
Viral delivery for gene therapy against cell movement in cancer.
TL;DR: This review highlights the illustrative examples of cancer gene therapy in clinical trials as well as preclinical data and includes proposals on methods to further enhance the safety and efficacy of oncolytic viral vectors in cancer gene Therapy.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
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