Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Identification of Human Junctional Adhesion Molecule 1 as a Functional Receptor for the Hom-1 Calicivirus on Human Cells
Stanislav V. Sosnovtsev,Carlos Sandoval-Jaime,Gabriel I. Parra,Christine M. Tin,Ronald W. Jones,Jo Soden,Donna Barnes,Jim Freeth,Alvin W. Smith,Kim Y. Green +9 more
TL;DR: The data indicate that entry of the Hom-1 vesivirus into these permissive human cell lines is mediated by the plasma membrane protein hJAM1 as a functional receptor, making it the first calicivirus to replicate efficiently in cultured human cells.
Journal ArticleDOI
Viral interactions with receptors in cell junctions and effects on junctional stability.
TL;DR: This paper describes how adenovirus can disrupt cell junctions, thereby effecting its release from basal surfaces of an infected epithelium to the apical or external environment.
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Toll like receptor 3 as an immunotherapeutic target for KRAS mutated colorectal cancer.
TL;DR: Investigation with KRAS mutated HCT116 cell line showed that effective expression of host TLR3 dampens the infection potential of reovirus by mounting a robust innate immune response, and strategies to mitigate theTLR3 response pathway can be utilized as a tool towards improved reov virus efficacy.
Journal ArticleDOI
Tight junction proteins occludin and ZO‐1 as regulators of epithelial proliferation and survival
TL;DR: A brief overview of ZO‐1 and occludin canonical (barrier‐related) functions, and a more detailed examination of their noncanonical functions are provided.
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Structure of Serotype 1 Reovirus Attachment Protein σ1 in Complex with Junctional Adhesion Molecule A Reveals a Conserved Serotype-Independent Binding Epitope
TL;DR: The structure of serotype 1 reovirus attachment protein σ1 alone and in complex with JAM-A is determined and it is revealed that both ρ1 proteins engage J AM-A with similar affinities and via conserved binding epitopes.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.