Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Posted ContentDOI
Genetic Polymorphisms and Molecular Mechanisms Mediating Oncolytic Potency of Reovirus Strains
Adil Mohamed,Derek R. Clements,Prathyusha Konda,Shashi Gujar,Patrick W. K. Lee,James R. Smiley,Maya Shmulevitz +6 more
TL;DR: The results depict an elaborate balance between reov virus replication and host-cell signaling to achieve optimal oncolytic reovirus efficacy.
Journal ArticleDOI
Targeting JAK/STAT Signaling Antagonizes Resistance to Oncolytic Reovirus Therapy Driven by Prior Infection with HTLV-1 in Models of T-Cell Lymphoma.
TL;DR: In this article, the authors investigate the effect of the JAK/STAT pathway inhibition on the resistance of T-cell leukemia virus type 1 (HTLV-1) cells to oncolytic virus therapy.
Book ChapterDOI
Physiology of Host-pathogen Interactions
Kim Hodges,Gail Hecht +1 more
TL;DR: This chapter provides a review of how a variety of bacteria interact with the human epithelium, focusing primarily on the pathogenesis of diarrheal disease and how microbial toxins are utilized pharmaceutically as a treatment for constipation or as potential anti-cancer agents.
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