Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Adenovirus Fiber Disrupts CAR-Mediated Intercellular Adhesion Allowing Virus Escape
Robert W. Walters,Robert W. Walters,Paul Freimuth,Thomas O. Moninger,Thomas O. Moninger,Ingrid M. Ganske,Joseph Zabner,Michael J. Welsh,Michael J. Welsh +8 more
TL;DR: It is found that following infection, human airway epithelia first released adenovirus to the basolateral surface, and Adenovirus fiber protein, which is produced during viral replication, facilitated apical escape.
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The Junctional Adhesion Molecule 3 (JAM-3) on Human Platelets is a Counterreceptor for the Leukocyte Integrin Mac-1
Sentot Santoso,Ulrich J. Sachs,Hartmut Kroll,Monica Linder,Andreas Ruf,Klaus T. Preissner,Triantafyllos Chavakis +6 more
TL;DR: Human JAM-3 was identified and described as a novel counterreceptor on platelets for the leukocyte β2-integrin Mac-1 and provides a novel molecular target for antagonizing interactions between vascular cells that promote inflammatory vascular pathologies such as in atherothrombosis.
Journal ArticleDOI
Tight junctions and human diseases.
Norimasa Sawada,Masaki Murata,Keisuke Kikuchi,Makoto Osanai,Hirotoshi Tobioka,Takashi Kojima,Hideki Chiba +6 more
TL;DR: The relationship between tight junctions and human diseases is summarized and Mutations in the claudin14 and theClaudin16 genes result in hereditary deafness and hereditary hypomagnesemia, respectively.
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Tight junctions as targets of infectious agents.
TL;DR: This review highlights and overview the tactics bacteria and viruses use to alter tight junctions during disease and identifies novel tight junction protein functions by using pathogens and their virulence factors as tools to study the cell biology of junctional structures.
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Reconstructing immune phylogeny: new perspectives
TL;DR: Findings blur traditional distinctions between adaptive and innate immunity and emphasize that, throughout evolution, the immune system has used a remarkably extensive variety of solutions to meet fundamentally similar requirements for host protection.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
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