Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Oncolytic reovirus induces intracellular redistribution of Ras to promote apoptosis and progeny virus release.
Katy A. Garant,Maya Shmulevitz,L Pan,Rémi M. Daigle,D-G Ahn,Shashi Gujar,Shashi Gujar,Patrick W. K. Lee +7 more
TL;DR: It is shown that reovirus alters the intracellular location of oncogenic Ras to induce apoptosis of H-RasV12-transformed fibroblasts and initiates apoptotic signaling events required for virus release and spread.
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Unraveling the complex genetics of familial combined hyperlipidemia.
TL;DR: The recent linkage and association studies and their replications are beginning to elucidate the genetic variations underlying the susceptibility to FCHL, one of the most common familial hyperlipidemias with a prevalence of 1%–6% in Western populations.
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Genomic structure, organization and promoter analysis of the human F11R/F11 receptor/junctional adhesion molecule-1/JAM-A
Tomasz Sobocki,Malgorzata B. Sobocka,Anna Babinska,Yigal H. Ehrlich,Probal Banerjee,Elizabeth Kornecki +5 more
TL;DR: The finding of multiple regulatory sites in the promoters supplements the biochemical evidence that the F11R has several different roles in the functional repertoire of endothelial cells, platelets and other cells.
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The reovirus sigma1 aspartic acid sandwich: a trimerization motif poised for conformational change.
Pierre Schelling,Kristen M. Guglielmi,Eva Kirchner,Bernhard Paetzold,Terence S. Dermody,Thilo Stehle,Thilo Stehle +6 more
TL;DR: Structural and biochemical analyses of mutants affecting the aspartic acid sandwich indicate that these residues and the corresponding chelated water molecules act as a plug to block the free flow of solvent and stabilize the trimer.
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Expression and Function of Tight Junctions in the Crypt Epithelium of Human Palatine Tonsils
Mitsuru Go,Takashi Kojima,Kenichi Takano,Masaki Murata,Shingo Ichimiya,Hiroshi Tsubota,Tetsuo Himi,Norimasa Sawada +7 more
TL;DR: Investigation of the expression and function of tight junctions in the epithelium of human palatine tonsils from patients with tonsillar hypertrophy or recurrent tonsillitis suggests unique expression of tightjunctions in human pal atine tonsillary epithelia, and the crypt epithellium may possess an epithelial barrier different from that of the surface epithelio.
References
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Journal ArticleDOI
Selective extraction of polyoma DNA from infected mouse cell cultures.
Journal ArticleDOI
Activators and target genes of Rel/NF-kappaB transcription factors.
TL;DR: It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
Journal ArticleDOI
Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
Journal ArticleDOI
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
Journal ArticleDOI
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.