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Open AccessJournal ArticleDOI

Junction Adhesion Molecule Is a Receptor for Reovirus

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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.
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This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.

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Proceedings ArticleDOI

The Hepatitis A Virus Cellular Receptor, HAVcR-1, Reduces the Integrity of Human Endothelial Tight Junctions.

TL;DR: In this article, the location, association and possible functionality of HAVcR-1 in human endothelial cells were investigated using immunohistochemistry and mRNA transcript by RT-PCR.
Book ChapterDOI

Sialic Acids in Nonenveloped Virus Infections.

TL;DR: This review describes how interactions between viruses and sialic acid-based glycan structures can be identified and characterized using a range of techniques and discusses what these interactions have taught us about sIALic acid engagement and opportunities to interfere with binding.

Surgically treated acute acalculous cholecystitis in critically ill patients

Jouko Laurila
TL;DR: Open cholecystectomy is one important contributing factor to reverse the course of multiple organ dysfunction in these patients, and Histological and immunohistological studies suggest that AAC is a manifestation of systemic inflammatory disease, while ACC is a local inflammatory and often infectious disease.
Journal ArticleDOI

Viruses as Therapeutic Agents Against Malignant Disease of the Central Nervous System

TL;DR: The authors’ concept of a ubiquitous reovirus receptor (terminally sialylated cellular glycoproteins) to mediate universal susceptibility of glioma cells may be simplifying a more complex process, involving multiple cellular surface recognition molecules interacting with various epitopes on the viral particle’s exterior.
References
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Journal ArticleDOI

Activators and target genes of Rel/NF-kappaB transcription factors.

TL;DR: It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
Journal ArticleDOI

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
Journal ArticleDOI

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
Journal ArticleDOI

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.
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