Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Tight junctions in the testis: new perspectives
Dolores D. Mruk,Cheng Cy +1 more
TL;DR: This review discusses largely how TJ proteins are exploited by viruses and cancer cells to cross endothelial and epithelial cells and how this information may apply to future studies investigating the movement of preleptotene spermatocytes across the BTB.
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Signalling at tight junctions during epithelial differentiation and microbial pathogenesis
TL;DR: Recent progress in the understanding of the molecular signalling mechanisms that drive junction assembly and function are reviewed, and the signalling processes by which tight junctions regulate cell behaviour and survival are discussed.
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The Viral σ1 Protein and Glycoconjugates Containing α2-3-Linked Sialic Acid Are Involved in Type 1 Reovirus Adherence to M Cell Apical Surfaces
Anna Helander,Katherine J. Silvey,Nicholas J. Mantis,Amy B. Hutchings,Kartik Chandran,William T. Lucas,Max L. Nibert,Marian R. Neutra +7 more
TL;DR: The results suggest that selective binding of type 1 reoviruses to M cells in vivo involves interaction of the type 1 σ1 protein with glycoconjugates containing α2-3-linked sialic acid that are accessible to viral particles only on M cell apical surfaces.
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Coxsackievirus and adenovirus receptor (CAR) is expressed in male germ cells and forms a complex with the differentiation factor JAM-C in mouse testis.
Momina Mirza,Julius Hreinsson,Mona-Lisa Strand,Outi Hovatta,Olle Söder,Lennart Philipson,Ralf F. Pettersson,Kerstin Sollerbrant +7 more
TL;DR: The results suggest that CAR in spermatozoa is inaccessible to adenovirus-based gene therapy vectors, and that the risk of germ line infection therefore is low.
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Viral escape from endosomes and host detection at a glance.
TL;DR: The different mechanisms that viruses have evolved to escape the endosomal compartment, as well as the counteracting cellular protection mechanisms, are described.
References
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TL;DR: It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.