Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Book ChapterDOI
Mechanisms of Apoptosis During Reovirus Infection
Penny Clarke,S. M. Richardson-Burns,S. M. Richardson-Burns,Roberta L. DeBiasi,Roberta L. DeBiasi,Kenneth L. Tyler,Kenneth L. Tyler +6 more
TL;DR: This review examines the mechanisms of reovirus-induced apoptosis and investigates the possibility that inhibition of apoptosis may provide a novel strategy for limiting virus-induced tissue damage following infection.
Journal ArticleDOI
Junctional adhesion molecule-A is overexpressed in advanced multiple myeloma and determines response to oncolytic reovirus
Kevin R. Kelly,Claudia M. Espitia,Weiguo Zhao,Erik Wendlandt,Guido Tricot,Fenghuang Zhan,Jennifer S. Carew,Steffan T. Nawrocki +7 more
TL;DR: It is reported that the reovirus receptor, junctional adhesion molecule-A (JAM-A) is highly expressed in primary cells from patients with MM and the majority of MM cell lines compared to normal controls, suggesting that Reolysin may be an effective agent for patients with relapsed/refractory disease due to their high JAM-B levels.
Journal ArticleDOI
Prediction of GCRV virus-host protein interactome based on structural motif-domain interactions
Aidi Zhang,Libo He,Yaping Wang +2 more
TL;DR: Although the predicted PPIs may contain some false positives due to limited data resource and poor research background in non-model species, the computational method still provide reasonable amount of interactions, which can be further validated by high throughput experiments.
Journal Article
Tissue-specific expression of occludin, zona occludens-1, and junction adhesion molecule A in the duodenum, ileum, colon, kidney, liver, lung, brain, and skeletal muscle of C57BL mice.
TL;DR: The results suggest that occludin, JAM-A, and ZO-1 genes are normally expressed in the intestine, kidney, liver, lung, lungs, and brain indicating that these factors may be essential for maintaining appropriate physiological concentration of ions, solutes and water.
Journal ArticleDOI
Transient infection of freshly isolated human colorectal tumor cells by reovirus T3D intermediate subviral particles.
W.J. van Houdt,Niels Smakman,D J M van den Wollenberg,Benjamin L. Emmink,Liesbeth M. Veenendaal,P. J. Van Diest,Rob C. Hoeben,I. H. M. Borel Rinkes,Onno Kranenburg +8 more
TL;DR: It is concluded that infection of human colorectal tumor cells by reovirus T3D requires processing of virions to ISVPs, but that oncolysis is prevented by a tumor cell response that aborts viral protein synthesis and the generation of infectious viral particles, irrespective of KRAS mutation status.
References
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