Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells
TL;DR: The cell biological properties of the actin cytoskeleton in polarized epithelial cells are discussed and the known mechanisms utilized by viral pathogens to manipulate this system in order to facilitate their infection are reviewed.
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Replication-incompetent virions of Japanese encephalitis virus trigger neuronal cell death by oxidative stress in a culture system.
TL;DR: The results presented here suggest that replication-incompetent UV-JEV damages actively growing neuronal cells through a ROS-mediated pathway.
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Overexpression of JAM-A in Non-Small Cell Lung Cancer Correlates with Tumor Progression
Min Zhang,Min Zhang,Wenting Luo,Bo Huang,Zihui Liu,Limei Sun,Qingfu Zhang,Xueshan Qiu,Ke Xu,Enhua Wang +9 more
TL;DR: It was observed that silencing JAM-A by small interfering RNA inhibited tumor cell proliferation and induced cell cycle arrest at the G1/S boundary, and played an important role in NSCLC progression.
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Two Distinct Phases of Virus-induced Nuclear Factor κB Regulation Enhance Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated Apoptosis in Virus-infected Cells
TL;DR: The results indicate that the ability of reovirus to inhibit NF-κB activation sensitizes HEK293 cells to TRAIL and facilitates virus-induced apoptosis in TRAIL-resistant cells.
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Retinoic Acid-induced Gene-1 (RIG-I) Associates with the Actin Cytoskeleton via Caspase Activation and Recruitment Domain-dependent Interactions
Amitava Mukherjee,Stefanie A. Morosky,Le Shen,Christopher R. Weber,Jerrold R. Turner,Kwang Sik Kim,Tianyi Wang,Carolyn B. Coyne +7 more
TL;DR: It is reported that retinoic acid-induced gene-I (RIG-I), an important viral RNA recognition molecule, is associated with the actin cytoskeleton and localizes predominantly to actin-enriched membrane ruffles in non-polarized epithelial cells.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.