Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Virus-associated disruption of mucosal epithelial tight junctions and its role in viral transmission and spread
TL;DR: In this paper, a review of possible molecular mechanisms of virus-associated disruption of mucosal epithelial junctions and its role in transmucosal viral transmission and spread is presented.
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Transcriptome-based identification of new anti-anti-inflammatory and vasodilating properties of the n-3 fatty acid docosahexaenoic acid in vascular endothelial cell under proinflammatory conditions
Marika Massaro,Rosanna Martinelli,Valentina Gatta,Egeria Scoditti,Mariangela Pellegrino,Maria Annunziata Carluccio,Nadia Calabriso,Tonia Buonomo,Liborio Stuppia,Carlo Storelli,Raffaele De Caterina +10 more
TL;DR: Endothelial exposure to DHA regulates novel genes and related pathways involved in stemness, cellular growth, cardiovascular system function and cancer, and included cytochrome p450 4F2(CYP4F2), transforming growth factor(TGF)-β2, Cluster of Differentiation (CD)47, caspase recruitment domain(CARD)11 and phosphodiesterase(PDE)5α.
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Investigation of the binding preference of reovirus sigma1 for junctional adhesion molecule A by classical and steered molecular dynamics.
TL;DR: A multireceptor mechanism is proposed for the binding preference of the attachment protein for JAM-A, which can be helpful for future viral infection and vector targeting studies.
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Reovirus double-stranded RNA genomes and polyI:C induce down-regulation of hypoxia-inducible factor 1α.
TL;DR: The data suggest that endo-lysosomal escape of reovirus genome into the cytoplasm is crucial for HIF-1α down-regulation; however, the retinoic acid-inducible gene-I (RIG-I) or interferon-β promoter stimulator-1 (IPS-1), which are involved in reov virus genome-induced innate immunity in the cy toplasm, did not play a crucial role inReovirus
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The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg–Gly–Asp motif
Astrid Rohrbeck,Markus Höltje,Andrej Adolf,Elisabeth Oms,Sandra Hagemann,Gudrun Ahnert-Hilger,Ingo Just +6 more
TL;DR: The results indicate that the RGD motif of C3 is at least one essential C3 motif for binding to host cells and that integrin is an additional receptor for C3 besides vimentin.
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