Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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The tight junction: a multifunctional complex.
TL;DR: A group of integral membrane proteins-occludin, claudins, and junction adhesion molecules-interact with an increasingly complex array of tight junction plaque proteins not only to regulate paracellular solute and water flux but also to integrate such diverse processes as gene transcription, tumor suppression, cell proliferation, and cell polarity.
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Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.
Matthew J. Evans,Thomas von Hahn,Donna M. Tscherne,Andrew J. Syder,Maryline Panis,Benno Wölk,Theodora Hatziioannou,Jane A. McKeating,Jane A. McKeating,Paul D. Bieniasz,Charles M. Rice +10 more
TL;DR: Using an iterative expression cloning approach, claudin-1 (CLDN1), a tight junction component that is highly expressed in the liver, is identified as essential for HCV entry and a new target for antiviral drug development.
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Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis
TL;DR: How the molecular architectures and interactions may represent a mechanistic basis for the function and regulation of junctions, focusing on junction assembly and permeability regulation, is emphasized.
Journal ArticleDOI
Tight junction proteins.
TL;DR: Advances in the knowledge of the molecular structure of TJ support previous physiological models that exhibited TJ as dynamic structures that present distinct permeability and morphological characteristics in different tissues and in response to changing natural, pathological or experimental conditions.
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Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms
Matthias Bruewer,Andreas Luegering,Andreas Luegering,Torsten Kucharzik,Torsten Kucharzik,Charles A. Parkos,James L. Madara,James L. Madara,Ann M. Hopkins,Asma Nusrat +9 more
TL;DR: These findings for the first time clearly separate the proapoptotic effects of IFN-γ and TNF-α from their abilities to disrupt barrier function.
References
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Sigma 1 protein of mammalian reoviruses extends from the surfaces of viral particles.
TL;DR: When sigma 1 protein was released from viral particles with mild heat and subsequently obtained in isolation, it was found to have a morphology identical to that of the fiber structures seen extending from the viral particles.
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Viruses and apoptosis
TL;DR: This paper aims to provide a history of Virology in Great Britain from the perspective of the 18th Century to the present day, focusing on the period 1833-1845.
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Role of NF-kappaB in immune and inflammatory responses in the gut.
TL;DR: The perpetuated activation of NF-κB in patients with active inflammatory bowel disease suggests that regulation of NF -κB activity is a very attractive target for therapeutic intervention, and strategies include antioxidants, proteasome inhibitors, inhibition of NF –κB by adenoviral IκBα expression vectors, and antisense DNA targeting of NF κB.
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Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM).
Aldo Del Maschio,Ada De Luigi,Ines Martin-Padura,Manfred Brockhaus,Tamas Bartfai,Paolo Fruscella,Luciano Adorini,Gianvito Martino,Roberto Furlan,Maria Grazia De Simoni,Elisabetta Dejana,Elisabetta Dejana +11 more
TL;DR: It is reported that BV11 administration was able to attenuate cytokine-induced meningitis in mice and Junctional adhesion molecule (JAM) may be a new target in limiting the inflammatory response that accompaniesMeningitis.
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Loss of Occludin and Functional Tight Junctions, but Not ZO-1, during Neural Tube Closure—Remodeling of the Neuroepithelium Prior to Neurogenesis
TL;DR: It is proposed that the loss of tight junctions from neuroepithelial cells reflects an overall decrease in their epithelial nature, which precedes the generation of neurons.